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Öğe APJ receptor A445C gene polymorphism in Turkish patients with coronary artery disease(E-Century Publishing Corp, 2015) Akçılar, Raziye; Yümün, Gündüz; Bayat, Zeynep; Donbaloğlu, Mehmet Okan; Erselcan, Kubilay; Ece, Ezgi; Genç, OsmanCoronary artery disease (CAD) is a disease in which a waxy substance called plaque builds up inside the coronary arteries. Apelin is a novel endogenous peptide with inotropic and vasodilatory properties and is the ligand for the angiotensin receptor-like 1 (APJ) receptor. We aimed to determine genotype and allele frequencies of APJ receptor A445C gene polymorphism in Turkish patients with CAD and healthy controls by RFLP-PCR. This study was performed on 159 unrelated CAD patients and 62 healthy controls. We obtained AA, AC and CC genotype frequencies in CAD patients as 41.5%, 49.1% and 9.4%, respectively. In the control group, frequencies of genotypes were found as 35.5% for AA, 48.4% for AC and 16.1% for CC. We did not observe difference in APJ receptor A445C polymorphism between CAD patients and healthy controls (chi(2) = 2.178; df = 2; P = 0.336). The A allele was encountered in 66% (210) of the CAD and 59.7% (74) of the controls. The C allele was seen in 34% (108) of the CAD and 40.3% (50) of the controls. Allele frequencies of interested genes were not significantly different between groups (chi(2) = 1.57; df = 1; p = 0.225). The frequencies of APJ receptor A445C genotype were not significantly different between control and patients. None of the three APJ receptor A445C genotypes, AA, AC and CC displayed significant difference in CAD patients. We did not find any difference in the clinical parameters except for weight and diastolic blood pressure levels in the AA, AC and CC genotypes of patients. Individuals with CC genotypes had significantly higher weight, systolic and diastolic blood pressure levels and systolic blood pressure than other genotypes, P <= 0.05. In addition, HDL-C level was found decreased, but this reduction was not statistically significant. Contrarily, the low levels of weight, SBP, DBP and TC were statistically significant in the subjects with AA genotype in CAD. In conclusion, CC genotype carriers may have more risk than other genotypes in the development of hypertension in CAD, but not AAgenotype carriers. We suggest that this polymorphism may not be a marker of CAD, but it may cause useful in function of the apelin/APJ system and may be a genetic predisposing factor for diagnostic processes and can be helpfull in finding new treatment strategies. We think that it is required to further comprehensive studies in order to make clear this situation in CAD.Öğe APJ receptor A445C gene polymorphism in Turkish patients with coronary artery disease (Meeting Abstract)(Wiley-Blackwell, 2016) Akçılar, Raziye; Yümün, Gündüz; Bayat, Zeynep; Donbaloğlu, Mehmet Okan; Erselcan, Kubilay; Ece, Ezgi; Genç, Osman[No Abstract Available]Öğe Association of APJ G212A gene polymorphisms with plasma APJ levels and coronary artery disease risk in Turkish population(E-Century Publishing Corp, 2016) Akçılar, Raziye; Yümün, Gündüz; Donbaloğlu, Mehmet Okan; Erselcan, Kubilay; Bayat, Zeynep; Genç, OsmanApelin and apelin receptor (APJ) are required for normal cardiovascular development. To investigate the relationship between the APJ G212A polymorphisms and plasma APJ levels and the risk of coronary artery disease (CAD), allele and genotype frequencies of the APJ G212A gene were analysed in were analysed in 152 Turkish patients with CAD and 110 controls by the PCR-RFLP method. The frequencies of genotype GG (57.2% vs 18.2%, P = 0.000, OR = 0.21, 95% CI 0.1 to 0.44) and frequencies of allele G (70.1% vs 46.8%, P = 0.000, OR = 2.65, 95% CI 1.84 to 3.83) at APJ G212A gene polymorphisms were significantly increased in CAD compared with controls. Although plasma APJ level of the patients with GG genotype was lower, It was not statistically significant. CAD patients had significantly lower plasma APJ levels as compared with controls (P = 0.018). On the basis of our results, patients with CAD seem to have lower APJ levels and higher APJ-212 GG genotype and G allele. These results suggested that the APJ G212A gene may be associated with risk for CAD and the APJ G212A gene may play a role in CAD in the Turkish population.Öğe Association of vaspin rs2236242 gene variants and circulating serum vaspin concentrations with coronary artery disease in a Turkish population(Wiley, 2021) Akçılar, Raziye; Yümün, Gündüz; Bayat, Zeynep; Donbaloğlu, Mehmet Okan; Gür, Özcan; Gürkan, Selami; Arık, ÖzlemCoronary artery disease (CAD) is the primary cause of death worldwide. Vaspin was a recently described adipokine, playing a protective role in many metabolic and cardiovascular diseases. This study aimed to assess the relation of serum vaspin levels and vaspin rs2236242 polymorphisms with CAD. The study included 105 healthy subjects and 105 CAD patients. Serum vaspin concentrations and vaspin rs2236242 polymorphisms were determined by enzyme-linked immunosorbent assay and polymerase chain reaction, respectively. There was a statistically significant difference between the genotypes of CAD patients (TT 26.7%, TA 71.4%, and AA 1.9%) and controls (TT 70.5%, TA 28.6%, and AA 1%;chi(2) = 40.3;df = 2;p = .000). The TA genotype increased the risk of CAD (odds ratio [OR] = 6.60; 95% confidence interval [CI] = 3.60-12.1;p = .000) as compared to the TT genotype. There was a statistically significant difference between the allelic distribution of CAD patients (T 62.4% and A 37.6%) and controls (T 84.8% and A 15.2%;chi(2) = 27.0;df = 1;p = .000). Those carrying the A allele had a higher risk of CAD compared to those with the T allele (OR = 3.35; 95% CI = 2.10-5.36;p = .000). The serum vaspin concentrations of the patients with TT, TA, and AA genotypes were 30.4 +/- 1.72, 28.4 +/- 2.89, and 36.4 +/- 6.38 pg/ml, respectively, and there was no significant difference between the serum vaspin levels and vaspin genotypes (p = .696). All of the above suggested that the vaspin rs2236242 polymorphism was associated with CAD in the Turkish population.Öğe Büyük safen ven yetmezliğinde manuel 980 nm lazer çıplak-uçlu fiber ile otomatik geri çekme sistemli 1470 nm radial fiber lazerin karşılaştırılması: Erken dönem etkinlik ve komplikasyonlarin analizi(2013) Gürkan, Selami; Gür, Özcan; Arar, Makbule Cavidan; Donbaloğlu, Mehmet Okan; Ege, TuranAmaç: Endovenöz lazer ablasyon, variköz ven tedavisinde en çok kabul gören tedavi seçeneklerinden biridir. Bu retrospektif çalışmanın amacı manuel 980 nm çıplak fiber lazer ile otomatik geri çekme sistemli 1470 nm radial fiber lazerin erken dönem etkinliklerinin karşılaştırılması. Gereç ve Yöntemler: Ekim 2011 ile Ocak 2013 arasında büyük safen ven yetmezliği sebebiyle endovenöz lazer ablasyon ile tedavi edilen 78 hasta ve 89 ekstremite incelendi. 980 nm lazer ve çıplak fiber ile tedavi edilen 40 hasta ve 45 ekstremite Grup 1 olarak tanımlandı. 1470 nm lazer radial fiber ve otomatik geri çekme sistemi ile tedavi edilen 38 hasta ve 44 ekstremite Grup 2 olarak tanımlandı. Ağrı, ekimoz, endurasyon, parestezi gibi lokal komplikasyonlar postoperatif 3, 7 ve 30. günlerde klinik olarak ve Doppler ultrasonografi ile değerlendirildi. Bulgular: Grup 1 ve grup 2de erken kapanma oranları sırasıyla %91 (n=41) ve %93 (n=41) idi. Bir aylık takipler sonunda her iki grupta da venöz klinik şiddet skorlarında belirgin derecede azalma oldu. Postoperatif ekimoz, endurasyon parestezi ve analjezik ihtiyacı grup 1de anlamlı derecede yüksek olmasına rağmen, major komplikasyonlar her iki grupta da görülmedi. Sonuç: Her iki tip lazer ile yapılan endovenöz lazer ablasyon işleminin erken dönem sonuçları tatmin ediciydi. Otomatik geri çekme sistemli 1470 nm dalga boyunda radial fiber kullanılarak yapılan büyük safen venin endovenöz lazer ablasyonunun etkili ve güvenli bir tedavi seçeneği olduğu söylenebilir.Öğe Characterization of the apelin-1860T>C polymorphism in Turkish coronary artery disease patients and healthy individuals(E-Century Publishing Corporation, 2015) Akçılar, Raziye; Yümün, Gündüz; Bayat, Zeynep; Donbaloğlu, Mehmet Okan; Erselcan, Kubilay; Ece, Ezgi; Genç, OsmanTo evaluate the association between the apelin -1860T>C polymorphism and plasma apelin levels in Turkish patients with coronary artery disease (CAD). A total of 276 individuals were enrolled in the present study, including 158 patients with CAD and 118 individuals without CAD as controls. The presence of the apelin -1860T>C gene polymorphism and plasma apelin levels were determined using polymerase chain reaction/restriction fragment length polymorphism and enzyme-linked immunosorbent assay, respectively. Significance was set at p?0.05 for all statistical analyses. The genotype and allele frequencies of interested genes were significantly different between groups (?2=10.2; df=2; p=0.006 and ?2=13.4; df=1; p=0.000, respectively). Frequency of CC genotype and the C allele of -1860T>C site was significantly higher in CAD patients compared to healthy controls. We found that individuals with the TC and CC genotypes were associated with an increased risk of CAD when compared with the TT genotype in CAD patients, and the adjusted ORs (95% CI) were 6.50 (1.27-33.0) and 6.39 (1.77-23.0), respectively. Plasma apelin levels were significantly lower in CAD patients compared to control group. Apelin level of CAD patient group having CC genotype of -1860T>C site was significantly lower compared to those having TT genotypes, but it was not statistically significant (p > 0.05). The homozygous CC genotype of apelin gene is associated with high risk of CAD. Apelin gene polymorphism -1860T>C is a significant predictor of predisposition to CAD in in Turkish population. © 2015, E-Century Publishing Corporation. All rights reserved.Öğe Comparison of Clinical Follow-up and Complications according to Cancer Types in Patients with Permanent Port Catheter Insertion due to Malignancy(2018) Gür, Özcan; Donbaloğlu, Mehmet Okan; Gürkan, SelamiAim: In patients diagnosed with cancer, port catheter insertion is of critical importance for the appropriate delivery of the treatmentand patient comfort. Aim of this study is to compare the patients placed subcutaneous port catheter in terms of the complications andthe port remaining open based on cancer types.Material and Methods: A total of 530 patients who had port catheter insertion in our clinic for chemotherapy between January 2011and December 2017 were included into the study. Of the cases, 234 (44.1%) were female and 296 (55.9%) were male; and the meanage was 57.90±10.18 years. The port catheters were placed subcutaneously under vascular ultrasonography and the position of thecatheter was checked using fluoroscopy. Patients underwent physical examination to check for hemorrhage or hematoma, andunderwent chest x-ray to check for pneumothorax or hemothorax. Patients were called in for checkup for wound-site infection and portthrombosis on the postoperative 10th and 30th days.Results: The majority of the patients who had port insertion were being followed up for gastrointestinal malignancies. Of the patients,224 (42.2%) had port catheter insertion due to colon cancer, 68 (12.8%) due to breast cancer, and 111 (20.9%) due to gastric cancer.Frequency of catheter thrombosis was statistically higher in cases with colon and breast cancer. Wound site infection was observedmore frequently in hematological malignancies.Conclusion: We suggest that, after port insertion, these complications can be reduced by using prophylactic anticoagulants for longterm port use in cases with breast and colon cancer, and by continuing empirical antibiotic treatment against endemic pathogens incases with hematological cancers.Öğe Comparison of drug eluting balloon versus standard balloon results in patients with below knee peripheral artery disease(Duzce University Medical School, 2018) Gür, Özcan; Donbaloğlu, Mehmet Okan; Gürkan, SelamiAim: Atherosclerotic peripheral arterial disease is frequently seen with critical leg ischemia. Despite the benefits of pharmacological agents in the lesions, the most effective treatment method is revascularization. In this study, we aimed to compare the results of drug-eluting balloon and standard balloon endovascular treatment methods. Material and Methods: One hundred and ninety-six patients who underwent infrapopliteal revascularization in Cardiovascular Surgery clinic in Namık Kemal University Hospital between January 2015 and June 2017 were included in the study. During the study, 100 patients were treated with drug-eluting balloon (DEB) (Lutonix, Bard, USA), while 96 patients were treated with standard balloon (PTA) (Nanocross, Medtronic, USA). The one-year patency rates were compared between the two groups. The patients were followed up at 1st, 3rd, 6th and 12th months after the procedure and followed by Ankle-Brachial Index (ABI) measurements and Rutherford classification. Results: Eighty three female and 113 male patients were included in the study. The mean age of the patients was 63.56±11.21. The median Rutherford classification was 4 (3-5) in the drug-eluting group according to the Rutherford classification and 4 (3-5) in the naked balloon group. During the 12-month follow-up period, limb salvage rate was 82.0% (n=82) in drug-eluting balloons and this rate was found to be 65.6% (n=63) in naked balloon group. In terms of amputation rates, the drug-eluting balloon group was found to be statistically superior (p=0.009). Conclusion: In this study, 12-month patency rates were found to be superior to naked balloons at 12-month patency rates and clinical follow-up. © 2018, Duzce University Medical School. All rights reserved.Öğe Derin ven trombozu bulunan hastalarda tedavi etkinliğinin değerlendirilmesi(2012) Gür, Özcan; Gürkan, Selami; Çakır, Habib; Özkaramanlı Gür, Demet; Donbaloğlu, Mehmet Okan; Ege, TuranAmaç: Derin venöz sistemde trombüs oluşumu ve venöz akımın kesilmesi derin ven trombozu (DVT) olarak adlandırılmaktadır. Çalışmada DVT tanısı alan hastalarda tedavi sonuçlarını değerlendirmeyi amaçladık. Yöntem: Kliniğimizde kasım 2010 mayıs 2012 tarihleri arasında doppler ultrasonografi ile derin ven trombozu tanısı almış toplam 73 hasta çalışmaya alındı. Hastaların yaş ortalaması 55.205 ± 18.12 (Min: 22, Max: 84) idi. Hastalara standart DVT tedavisi uygulandı. Olgular tarafımızdan 6. ay'da doppler ultrasonografi ile venöz sistemleri tekrar değerlendirildi. Hastalar etyolojik faktörlere göre incelendi. Bulgular: Otuz hasta cerrahi sonrası yetersiz profilaksi, 9 hasta malignite, 34 hasta ise idiyopatik idi. 39 olguda sol alt ekstremite, 21 olguda sağ alt ekstremite ve 13 olguda ise her iki alt ekstremitede derin ven trombozu mevcuttu. 6 ay sonunda doppler ultrasonografi ile tüm hastaların tromboze ven segmenti değerlerdirildi. 54 olguda (%73) tromboza ait radyolojik bulgu kalmamış olup, 12 olguda (%16.4) rekanalize tromboze segment, 7 olguda (%8.5) ise trombozun devam ettiği görülmüştür. Sonuç: Derin ven trombozu tedavisi ve profilaksisinin yeterli yapılması rekürrensi azaltırken rekanalizasyon ve tromboz lizisini arttırmaktadır. Olguların mortalite ve morbiditesinin azalmasını sağlamaktadır.Öğe Dizaltı Periferik Arter Hastalığı Bulunan Olgularda İlaç Salınımlı Balon ile Çıplak Balon Sonuçlarının Karşılaştırılması(2018) Gür, Özcan; Donbaloğlu, Mehmet Okan; Gürkan, SelamiAmaç: Dizaltı aterosklerotik periferik arter hastalığı ile sıklıkla kritik bacak iskemisi tablosuyla karşılaşılmaktadır. Lezyonlarındafarmakolojik ajanların yararlarına rağmen günümüzde en etkili tedavi yöntemi revaskülarizasyondur. Bu çalışmada dizaltıendovasküler tedavi yöntemlerinden ilaç salınımlı balonlar ile çıplak balon sonuçlarının karşılaştırılması amaçlanmıştır.Gereç ve Yöntemler: Namık Kemal Üniversitesi Hastanesi Kalp Damar Cerrahisi kliniğinde, Ocak 2015 ve Haziran 2017 tarihleriarasında infrapopliteal revaskülerizasyon yapılan 196 hasta çalışmaya dahil edildi. Çalışma sırasında 100 hasta ilaç salınımlı balon ile(Lutonix, Bard, USA) ile tedavi edilirken, 96 hasta standart balon (Nanocross, Medtronic, USA) ile tedavi edildi. İki grup arasında biryıllık açık kalma oranları karşılaştırıldı. Hastalar işlem sonrası birinci, üçüncü, altıncı ve on ikinci aylarda kontrole çağrılarak Ayakbileği-Kol indeksi (ABI) ölçümleri ve Rutherford sınıflaması ile takip edildi.Bulgular: Çalışmaya 83 kadın, 113 erkek hasta alındı. Hastaların ortalama yaşı 63,56±11,21 idi. Rutherford sınıflamasına göre ilaçsalınımlı balon grubunda başlangıç Rutherford evrelemesi ortancası 4 (3-5) iken çıplak balon grubunda da 4 (3-5) olarak tespit edildi.Her iki grup arasında işlem sonrası 12 aylık takiplerde ekstremite kurtarma oranı ilaç salınımlı balonlarda %82,0 (n=82) olarak tespitedilirken çıplak balonlarda bu oran %65,6 (n=63) olarak tespit edildi. Ampütasyon oranları açısından ilaç salınımlı balon grubuistatistiksel olarak üstün bulunmuştur (p=0,009).Sonuç: Çalışma sonucunda 12 aylık açık kalma oranları ve klinik takiplerde ilaç salınımlı balonlar çıplak balonlara göre daha üstünolarak bulunmuştur.Öğe Do treatment methods for deep vein thrombosis have different effects on post-thrombotic syndrome and the quality of life?(Sage Publications Ltd, 2023) Donbaloğlu, Mehmet Okan; Gürkan, Selami; Gür, ÖzcanObjective: This study aimed to compare the effects of interventional methods and medical therapy in patients with acute proximal deep vein thrombosis (DVT) on the risk of development of post-thrombotic syndrome (PTS) and the quality of life during the follow-up period.Patients and methods: Clinical statuses of the patients who were treated medical therapy alone or medical therapy and endovascular treatment for acute proximal (iliofemoral-popliteal) DVT between 1st January 2014 and 1st November 2022 were reviewed retrospectively. The study included 128 patients who received interventional treatment (Group I) and 120 patients who received medical therapy alone (Group M). The mean age of the patients was 52.98 +/- 12.45 years in Group I and 55.60 +/- 16.15 years in Group M. Patients were classified as provoked or unprovoked and by LET scale (lower extremity thrombosis level scale). Patients were followed-up for 1 year using Villalta scores and VEINES-QoL/Sym questionnaire. LET scale was evaluated based on the results of lower extremity venous Doppler ultrasound (DUS).Results: No early acute phase mortality was observed. LET classification showed that there is higher proximal involvement in Group I (Table 1). Recurrence rate was 6.25% (8 patients) in Group I and 21.66% (26 patients) in Group M (p < .001). Pulmonary embolism was not observed in either group. At 12-month follow-up, the number of patients with a Villalta score of >= 5 was 8 (6.25%) in Group I and 81 (67.5%) in Group M (p < .001), while the mean VEINES-QoL/Sym scale score was found to be 72.5 +/- 6.35 in Group I and 40.2 +/- 9.31 in Group M (p < .001). The rates of anticoagulant-associated bleeding were 3.12% (4 patients) in Group I and 6.66% (8 patients) in Group M. The mean complete recanalization rates calculated using DUS at year 1 was found to be 63.28% (81 patients) in Group I and 9.16% (11 patients) in Group M (p < .001). Conclusion: When deep vein thrombosis is treated using interventional methods, lower Villalta scores are detected after 1 year of follow-up. Development of post-thrombotic syndrome is reduced substantially. According to VEINES-QoL/Sym quality of life (QoL) scale, QoL is higher in patients who underwent interventional procedures. Interventional treatment provides persistent benefit in the short and medium terms especially in DVT with proximal involvement.Öğe Does body mass index have an effect on clinical and pain after endovenous therapy? A retrospective study(Sage Publications Ltd, 2021) Donbaloğlu, Mehmet OkanObjectives: The study aims to investigate the change in postoperative clinic, pain, and general quality of life of patients who were operated on due to chronic venous disease (CVD), according to their body mass index (BMI). Materials and methods: 150 patients (30-45 years) who were treated with cyanoacrylate embolization for CVD between January 2017 and February 2020 were analyzed retrospectively. The clinical (C) category of clinical, etiology, anatomy, and pathophysiology (CEAP) classification venous clinical severity score (VCSS) and visual analog scale (VAS) questionnaires were applied to the patients before and after the operation periodically. The patients were surveyed preoperatively and postoperatively at 1st, 6th, 12th, and 24th months. Results: The patients were divided into three groups according to their BMI. In the comparison between normal and overweight participants, venous reflux, CEAP C categories, and VAS scores were not statistically significantly different in preoperative and postoperative periods. In the comparison between normal and obese participants, CEAP C categories, VCSS, and VAS scores were statistically significantly different in postoperative periods. There was no statistically significant difference in terms of venous reflux preoperatively and postoperatively in all three groups. Conclusions: The study showed that the increase in BMI had negative effects on the CEAP C categories, pain, and quality of life independently of the venous reflux of CVD.Öğe Effects of moderate pressure distention on the proximal and distal sections of the saphenous vein(E-Century Publishing Corp, 2016) Yümün, Gündüz; Gür, Özcan; Gelincik, İbrahim; Ay, Derih; Donbaloğlu, Mehmet Okan; Gürkan, Selami; Özkaramanlı Gür, DemetStudies have shown that the distention and traction of a vein leads to the loss of cells and the function of the endothelia. Here, we aimed to compare the effects of pressure distention on the proximal and distal parts of the saphenous vein. Twenty patients were enrolled in this study. The proximal and distal saphenous vein segments were distended to three different pressure levels for two minutes: 100 mmHg, 200 mmHg, and 300 mmHg. In addition, the proximal and distal parts of the saphenous vein were compared with the immunohistochemical examinations and the organ bath system. The endothelial cell loss was similar in the proximal and distal segments at 300 mmHg. However, the endothelial cell loss rate was greater in the proximal segments than the distal segments at 100 mmHg and 200 mmHg (P=0.02 and P=0.06, respectively). The relaxation response of the proximal samples distended to 100 mmHg and 200 mmHg was significantly decreased when compared to the distal segment samples (P=0.049 and P=0.047, respectively). Furthermore, there was no relaxation response in the segment samples distended to 300 mmHg. While preparing the graft, inflations with pressures lower than 100 mmHg result in less endothelial damage, and are relatively protective on the graft functions. In this study, we have shown that the endothelial tissue of the distal saphenous vein is more resistant to moderate pressure.Öğe Evaluation of Treatment Activity in Patients With Deep Venous Thrombosis(Cukurova Univ, Fac Medicine, 2012) Gür, Özcan; Gürkan, Selami; Çakır, Habib; Özkaramanlı Gür, Demet; Donbaloğlu, Mehmet Okan; Ege, TuranPurpose: Deep vein thrombosis (DVT) refers to thrombi formation and blood stasis in the deep veins of the extremities. This study was to determine the effectiveness of DVT treatment in our clinic. Method: All of 73 patients who diagnosed Deep Venous Thromboses with dupplex ultrasoun between december 2010 and may 2012, at our institution were enrolled in this study. The mean age of the patients was 55.205 +/- 18.12 (Min: 22, Max: 84). Standart DVT treatment was applied. We re-evaluated the change in deep venous system using follow-up Dupplex ultrasonography after 6 months. The patients were observed according to etiology. Results: Etiologic factors were insufficient prophylaxis after surgery (30 patients), malignancy (9 patients) and idiopathic (34 patients). Deep venous thrombosis existed left lower extremity (n=39), right lower extremity (n=21) and bilateral lower extremity (n=13). Thrombosis vein segment of all patients were evaluated with duplex ultrasonography after 6 months. Radiologic findings of thrombosis disappeared in 54 patients (73%). Thrombosis segment were recanalization in 12 patients (16.4%). Thrombosis was not recovery in 7 patients (8.5%). Conclusion: If treatment and prophylaxis of deep venous thrombosis perform enough, recurrence decreases and recanalization and lysis of thrombosis increase. Eventually mortality and morbidity of cases decrease.Öğe Investigation of the Efficacy of the Use of Cyanoacrylate in the Treatment of Venous Insufficiency: Single Center Short and Mid-Term Retrospective Results(2021) Donbaloğlu, Mehmet OkanObjective: The present study aimed to evaluate the efficacy of cyanoacrylate embolization and to analyze the short- to mid-term results of cyanoacrylate embolization procedures to treat great saphenous vein insufficiency. Materials and Methods: 582 patients treated with cyanoacrylate embolization due to severe incompetence of the great saphenous vein were included in the study and analyzed retrospectively. Patients were evaluated clinically on the first month, sixth month, first year and second year after the operation. The treated limbs were evaluated and recorded separately. Results: In the postoperative period, reflux was assessed at the level of 0.5 sec in 2 (0.3%) patients in the 12th month, and 1 sec in 2 (0.3%) patients in the 24th month. The patients stated that minor complications such as pain, burning, fatigue, itching 98.8% healing in the 12th month. Deep vein thrombosis, which is a major complication, was seen in 1(0.2%) patient at the 12th month. Preoperatively documented mean venous clinical severity scorefrom 8.86±1.59 to 0.88±0.61 (pÖğe Is using metaproterenol sulfate reliable in hypertension management during the coronary artery bypass graft surgery in terms of graft patency?(Via Medica, 2021) Donbaloğlu, Mehmet Okan; Gür, Özcan; Gürkan, Selami; Kaykisiz, E.K.Introduction: Coronary artery bypass graft (CABG) surgery that is a basic revascularization method is used commonly and hypertension appears frequently during and after CABG operations. In the treatment of hypertension, metaproterenol sulfate (MS) is one of the main agents; however, the effects of this agent on grafts are not known at an adequate level. The aim of the present study was to determine whether MS could be used safely in CABG operations by examining its effects on coronary grafts. Material and Methods: This cross-sectional, prospective, experimental study was conducted at a university hospital. In this study, internal thoracic artery (ITA), radial artery (RA) and saphenous vein (SV) graft materials were studied in organ bath in patients who underwent CABG surgery between 2013 and 2016. In the organ bath, 10-6 phenylephrine was added to the grafts to ensure that the ITA, RA and SV grafts contracted submaximally. Then, by adding MS with the cumulative method, the resulting relaxation results were recorded and dose-response curves were created. The p < 0.05 was considered as significant. Results: A total of 30 patients were included in the study. The average age of the participants was 59.3 (45-81) years. Minimum 1 and maximum 6 grafts (2.96 in average) were taken from all patients. Relaxation response was formed in the ITA at a rate of 40.49% ± 13.52, in the RA at a rate of 28.41% ± 9.08 and in the SV at a rate of 23.87% ± 8.36 by adding MS with the cumulative method. In the statistical work that was done by comparing the relaxation values among the SV grafts, ITA and RA grafts, it was determined that the efficacy of MS in the SV grafts was significantly lower when compared with the ITA and RA grafts. Conclusions: In the present study, it was concluded that the risk of developing vasospasm was low in all three grafts when MS was used in intraoperative and postoperative periods. However, in the long-term, this made us consider that better graft patency rates might be obtained. Multicenter in-vivo studies with larger patient groups are needed to support our findings. © 2021 Via Medica.Öğe Left atrial myxoma combined with coronary artery disease in an elderly patient(2018) Yümün, Gündüz; Gürkan, Selami; Donbaloğlu, Mehmet OkanCardiac myxoma associated with coronary artery disease is a rare pathology in an elderly patient. Herein wepresent an 81-year-old woman undergoing simultaneous surgical treatment for left atrial myxoma combinedwith coronary artery disease. The postoperative course of the patient was uneventful. The initial removal ofmass should be performed to prevent systemic embolization of tumor fragmentsÖğe Retrospective evaluation of totally implantable venous access port devices: Early and late complications(Imprimatur Publications, 2015) Gürkan, Selami; Seber, Selçuk; Gür, Özcan; Yetişyiğit, Tarkan; Donbaloğlu, Mehmet Okan; Özkaramanlı Gür, DemetPurpose: The role totally implantable vascular devices (TI-VAD) have an important role in providing care to cancer patients who require continuous or frequent venous access route either for their primary or supportive care treatments. This retrospective study aimed to analyze the efficacy of TIVAD and device-related complications. Methods: A total of 324 consecutive patients (185 male, 139 female, median age 56 years, mean 48 +/- 10.91; min:16, max:87) who were implanted with TIVAD between January 2012 May 2014 were included. We retrospectively assessed all TIVAD complications and focused on early and late complications. Results: A total of 324 devices were implanted successfully without major complications. The overall complication rate was 33.95% (N=110). Of them, 87(26.85%) were early and 23 (7.09%) were late complications. In total, 39 (11.23%) catheters were removed, in 8 (2.30%) patients due to complication and in 31(9.56%) due to the end of treatment. Conclusion: Most of the complications of TIVAD were early without requiring removal. Port catheters for chemotherapy are safe and well tolerated with acceptable complication rates.Öğe Subtotal Pacemaker Exteriorisation Due to Hematoma of Pocket: A Case Report(Elsevier Ireland Ltd, 2013) Gürkan, Selami; Gür, Özcan; Alpsoy, Şeref; Donbaloğlu, Mehmet Okan; Güler, N.[No Abstract Available]Öğe Successful Endovascular Treatment of a Patient with Subclavian Steal Syndrome and Bovine Arch' Anomaly: Case Report(2016) Gürkan, Selami; Gür Özkaramanlı, Demet; Gür, Özcan; Donbaloğlu, Mehmet OkanProksimal subklavyan arter stenozu, vertebrobaziler yetmezlikten dolayı subklavyan çalma sendromuna neden olabilir. Son yıllarda bu lezyonların endovasküler tedavileri yaygın bir şekilde kullanılmaktadır. Bovine ark anomalisi ve proksimal subklavyan arter stenozu olan 58 yaşında erkek hastayı sunmayı amaçladık. Doppler ultrasonografi sol vertebral arterdeki hemodinamik bozukluğu gösterdi. Bu çalışmada, subklavyan çalma sendromunun başarılı endovasküler tedavisini sunduk.
