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Öğe A New Insulin Sensitivity Index Derived From Fat Mass Index and Quantitative Insulin Sensitivity Check Index(Namık Kemal Üniversitesi, Tıp Fakültesi, 2015) Donma, Mustafa Metin; Donma, Orkide; Topçu, Birol; Aydın, Murat; Tülübaş, Feti; Nalbantoğlu, Burçin; Demirkol, Muhammet; Gürel, AhmetAim Obesity has recently become one of the most important health problems throughout the world. This fact led to the controversies on the clinical use of insulin sensitivity indices. Indices previously described or introduced in this study have been evaluated to choose one, which is capable of exhibiting significant distinctions between healthy children and those involved in the classes of childhood obesity. Material and Methods A total of 179 girls; 81 morbidly obese(MO), 42 obese(O), 16 overweight(OW) and 40 normal(N) participated in the study. Groups were constituted based upon age- and sex-specific body mass index percentiles tabulated by World Health Organization. Homeostasis Model Assessment of Insulin Resistance(HOMA-IR), HOMA-IR/BMI, log HOMA-IR, fasting glucose/fasting insulin ratio(FGIR), quantitative insulin sensitivity check index(QUICKI), Raynaud, reciprocal insulin indices and also new indices HOMAIR*BMI, HOMA-IR*fat mass index(FMI), QUICKI*BMI, QUICKI*FMI were calculated. The cut-offs 3.16 and 2.5 for HOMA-IR, 7 and 6 for FGIR, 0.357 and 0.328 for QUICKI were evaluated to estimate insulin resistance. Statistical analyses were performed with Predictive Analytics SoftWare(PASW) Statistics 18. Results and Conclusion QUICKI*FMI was able to make a clear-cut separation between the groups. A new trilogy for cut-offs (HOMA>2.5, FGIR<7, QUICKI<0.328); each giving the similar results, has been suggested. Multifaceted character of QUICKI was also introduced. QUICKI was capable of discriminating MO from O when 0.328 cutoff was used, and O from OW when 0.357 cut-off was used. QUICKI*FMI index, a new one, was unique in detecting the advanced level of differences(p?0.005) between N-OW, OW-O and O-MO groups during childhood obesity.Öğe A newborn infant with significant pneumothorax treated with administration of oxygen via hood(Cocuk Sagligi ve Hastaliklan Dergisi, 2016) Küçüktaşçı, Kazım; Samancı, Nedim; Demirkol, Muhammet; Koşumcu, İhsan; Taşkaldıran, Duygu.; Ersöz Güngör, Zeynep; Balcı, HalilPneumothorax is the most common air-leak syndrome resulting in significant morbidity and mortality in neonates. It can develop spontaneously, as well as it can be seen as a result of a predisposing factor or a pulmonary problem. Treatment of the cases with pneumothorax depends on the clinical condition. Small, asymptomatic cases with pneumothorax resolve spontaneously, although symptomatic and clinically deteriorated cases should be drained. We presented a case of a newborn with a significant pneumothorax, who was clinically and hemodynamically stable under treatment with administration of oxygen with hood, without any surgical intervention although he had symptoms of respiratory distress.Öğe A rare association: Unilateral fibromatosis colli and contralateral clavicle fracture in a newborn(Elsevier Ireland Ltd, 2015) Donma, Mustafa Metin; Demirkol, Muhammet; Yıldırım Güzelant, Aliye; Özçağlayan, Ömer; Gülek, B.; Karakoyun, Özgür; Donma, OrkideFibromatosis colli (FC) is a cause of muscular torticollis that can be diagnosed by careful physical examination. In most of the cases, follow up and exercise is enough for treatment, although rare cases require surgical intervention. Clavicle fracture can be a complication of struggling vaginal parturition and usually treated by close follow up. This case was reported and discussed as a rare association that is not found in the literature and the first case diagnosed in the newborn period with unilateral FC associated with contralateral clavicle fracture in a non-macrosomic infant who was treated with dramatic response to physical therapy. (C) 2015 Elsevier Ireland Ltd. All rights reserved.Öğe Association of Thiol Disulfide Homeostasis with Childhood Asthma(Georg Thieme Verlag Kg, 2016) Kaya, Buket Kubra; Aydın, Murat; Donma, Mustafa Metin; Demirkol, Muhammet; Biçer, Cemile; Erel, ÖzcanThe aim of this study is to evaluate the oxidative stress level in asthmatic children in terms of the disulfide/thiol ratio, to research the role the disulfide/thiol ratio plays in the pathogenesis of the malady, and to determine the usefulness of the disulfide/thiol ratio as an indicator of the oxidation stress situations in patients with asthma. We report that the disulfide/thiol ratio and disulfide levels were significantly higher in the asthmatic group than in the control group. All in all, high levels of disulfide/thiol ratios in asthmatic children are thought to play roles in the pathogenesis of the disease.Öğe Asymmetric dimethylarginine as risk marker of endothelial dysfunction in obese children(Wiley-Blackwell, 2016) Aydın, M.; Donma, Mustafa Metin; Donma, Orkide; Nalbantoğlu, Burçin; Tülübaş, Feti; Topçu, Birol; Gürel, A.; Demirkol, Muhammet; Yılmaz, A.; Küçükyalçın, V.[No Abstract Available]Öğe Effect of Use of Mobile Phone And Electronic Devices in The Childhood And Adolescence on Body Mass Index And Sleep Time As Well As Fast-Food Consumption And Physical Activity(Namık Kemal Üniversitesi, Tıp Fakültesi, 2014) Muhderem, Nazlı; Demirkol, Muhammet; Topçu, Birol; Beldek, Kader; Nergiz, Merve; Çömlek, Büşra; Yorganlı, Ece; Sevinç, Erva; Acar, Çiğdem; İsmailoğlu, İbrahim Halil; Özcan, Selin; Donma, Orkide; Donma, Mustafa MetinAim In this study, we aimed to find out the effects of use of mobile phone (MP)’s and electronic device (ED)’s on body mass index(BMI), sleep-time, consumption of fast-food (FF) and exercise-period of children and adolescents. Material and Methods Questionnaires were applied related to time-periods of MPs/EDs, sleeping and exercise plus FF consumption. Weight, height, waist and hip circumferences were taken. Data of 50 cases using MPs and data of 50 cases who do not use MPs were compared. PASW-18 statistics program, chi-square, independent sample and Mann-Whitney U Test were used. p?0,05 was accepted as statistically significance value. Results Boy/girl ratio was 1/1 in MP(-) group, and it was 0,92 in CT(+) group. Mean age was 121.32±21.22 in MP(-) group, and it was 147.34±24.63 in MP(+) group. Daily usage period of EDs was 234.10±114.49 in MP(-) group, and it was 286.70±116.32 in MP(+) group (p?0,05). BMI of MP(-) group was 19.01±5.08; and it was 20.88±4.74 in the MP(+) group (p?0.05). Daily sleep-time was 9.42±1.08 in the MP(-) group, and it was 8.74±1.06 in the MP(+) group (p?0.05). Weekly frequency of consumption of FF and sweetened-foods in MP(-) group was 2.38±2.85; and it was 5.14±6.93 in the MP(+) group (p?0,01). Daily active-period of MP(-) group was 147.74±254.04, and it was 95.60±64.77 in the MP(+) group (p?0.05). Conclusion Our study emphasizes that decreasing the time spent with EDs, especially with MPs, can be beneficial for minimizing consumption of FF and sweetened foods, prevention of development of obesity, maximizing the time for physical activity and providing optimum sleep time period in children and adolescents.Öğe Serum Endocan Levels in Children with Community-Acquired Pneumonia(Mary Ann Liebert, Inc, 2017) Paketçi, Cem; Paketçi, Ahu; Erdede, Özlem; Demirkol, Muhammet; Güzel, SavaşIn this study, it was aimed to compare the levels of serum endocan with commonly used markers, and also to define the suitability for determination of disease severity in patients with community-acquired pneumonia (CAP). The study included 60 patients and 28 healthy subjects. Pneumonia severity was determined according to British Thoracic Society guidelines for the management of CAP in children. Serum levels of endocan and C-reactive protein (CRP) and white blood cell (WBC), and neutrophil count were measured. Serum endocan levels were increased in patients with CAP. CRP levels, WBC count, neutrophil count and neutrophil lymphocyte ratio were also higher in the CAP group than healthy control group. Endocan was correlated with CRP and WBC count and disease severity. For the identification of CAP, the area under the receiver operating characteristic (ROC) curve of CRP was acceptable for CRP, but not for endocan (0.812 and 0.649, respectively). ROC analysis for endocan to differentiate between severe CAP (n = 29) and mild-moderate CAP (n = 31) gave an area under the curve of 0.769 compared to 0.667 for CRP. Serum endocan levels increase in patients with CAP and can therefore be a useful marker in diagnosis and as a particular indicator of the treatment in the clinical assessment of CAP disease severity. Serum endocan levels of patients with severe CAP were higher compared with patients with mild-moderate CAP. These results revealed that endocan might be a useful indicator of severity of CAP.Öğe Trakya Bölgesinde Pediatrik Yoğun Bakım Ünitesinde Akut Zehirlenme Vakalarının Retrospektif Analizi(2018) Nalbantoğlu, Ayşin; Çelik Güzel, Eda; Demirkol, Muhammet; Samancı, Nedim; Albantoğlu, BurçinAmaç: Bu çalışmadaki amacımız, Trakya bölgesinde çocuk yoğun bakım ünitesinde takip ve tedavileri yapılan zehirlenme vakalarının özelliklerini belirlemek ve önlemlerin alınmasına rehberlik etmektir.Gereçler ve Yöntem: Namık Kemal Üniversitesi Tıp fakültesi hastanesi çocuk yoğun bakım ünitesinde Ocak 2012-Ağustos 2016 tarihleri arasında zehirlenme nedeniyle takip ve tedavi edilmiş çocuklar çalışmaya dahil edildi. Bilgiler hasta kayıtları geriye dönük taranarak toplandı. Yaş, cinsiyet, zehirlenme etkeni, yeri ve nedeni, hastaneye başvuru şekli ve tedavi yöntemleri değerlendirildi. Veriler tanımlayıcı yöntemler ve ki-kare testi kullanılarak değerlendirildi; p değeri <0.05 olan istatistiksel farklılıklar anlamlı kabul edildi.Bulgular: Yaşları 6 ay-18 yaş arasında olan 172 hastanın kayıtları retrospektif olarak tarandı, 113 (%65,70) hasta kız, 59 (%34,30) hasta erkekti ve ortalama yaşları 6,61±5,36 yaş arasındaydı. Zehirlenme vakalarının büyük çoğunluğu (%52) 0-4 yaş arasında bulundu. Çoğu vakada (%91,90) zehirlenme evde ve oral yol ile (%95,90) gerçekleşmişti. Mevsimlere göre bakıldığında zehirlenme vakalarının birçoğu yaz ayında meydana gelmişti. Zehirlenme nedenlerine bakılacak olursa %70,30’ü kaza sonucu meydana gelmişti, intihar amacı ile oluşan zehirlenmelerin %98’i kız çocuklarındaydı. Zehirlenmeler en sık ilaçlar ile gerçekleşmiş (%78,60), ikinci en sık neden korozif maddeler (%10,80) ve vakaların %3,80’inde temizlik maddeleri takip etmekteydi. İlaçlar arasında antidepresanlar en sık (%25,85) zehirlenme etkeni olarak bulundu ve akut zehirlenme nedeni ile takip edilen 172 hastada ölüm bildirilmedi.Sonuç: Zehirlenmelerin en sık 0-4 yaş arası çocuklarda görülmesi ailelerin bu konuda eğitilmelerinin ne kadar önemli olduğunu göstermektedir. Bölgemizde hem kaza sonucu hem de intihar amaçlı gelişen zehirlenmeler kız çocuklarda daha fazla görülmüştür. Özellikle kaza sonucu gelişen zehirlenmelerin literatürden farklı olarak bu bölgede kız çocuklarda daha fazla görülmüş olması dikkat çekicidir. Çocukluk çağı zehirlenmelerinin önlenmesinde, kapsamlı araştırmalar yapılması ve ailelerin eğitilmesinin mortalite ve morbiditenin azaltılmasında etkili olacağı inancındayız.
