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    Evaluation of Serum Endocan Levels in Sensorineural Hearing Loss
    (Aves, 2019) Gültekin, Erdoğan; Ersözlü, Tolga; Demirel, Oral Burak; Kaymaz, Özlem; Topçu, Birol; Çiftçi, Zafer
    OBJECTIVES: The aim of this study was to reveal the possible role of endothelial dysfunction in sensorineural hearing loss (SNHL) by determining the serum endocan levels of patients with varying degrees of SNHL. MATERIALS and METHODS: Patients with documented SNHL and healthy controls were included in the study, whereas those with a known history of chronic inflammatory condition were excluded. In addition, a recent history of use of glucocorticoids, nonsteroid anti-inflammatory drugs, or any ototoxic medications was also considered as an exclusion criterion due to its potential impact on endocan synthesis and metabolism. Following overnight fasting, blood samples were collected, and serum endocan levels were measured. For statistical analysis of the data, PASW Statistics for Windows version 18 was used. RESULTS: The comparison of the subgroups yielded no statistically significant difference between the control and mild-to-moderate SNHL groups. Despite the increase in hearing loss, the difference between the endocan levels in these patients did not increase proportionately and was not statistically significant (p>0.05). The patients in the severe SNHL group had a higher level of serum endocan than those in other groups, and the difference was statistically significant (p<0.05). CONCLUSION: The serum endocan levels failed to show a proportionate increase with increasing degree of SNHL, indicating that there is no precise association between SNHL and serum endocan levels. The serum endocan levels of patients with SNHL did not significantly differ from those of the healthy controls.
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    Evaluation of the Hearing System in Chronic Obstructive Pulmonary Disease Patients
    (2021) Demirel, Oral Burak; Ersözlü, Tolga; Deniz, Mahmut
    Aim: This study aimed to examine the effect of chronic hypoxemia on auditory functions in chronic obstructive pulmonary disease (COPD) patients.Materials and Methods: Sixty patients who had pulmonary function test (PFT) and diagnosed with COPD were included in the study. Four studygroups and a control group were created in the study. Each study group was determined based on forced expiratory volume (FEV1) and FEV1/forcedvital capacity (FVC) ratio. Groups consisted of mild, moderate, severe and very severe COPD patients. Each group included 15 patients. The controlgroup consisted of 30 patients with an FEV1/FVC ratio of >70%. All patients underwent pure tone audiometry and otoacoustic emission (OAE) test.Results: According to the audiological evaluation, a statistically significant difference was found between the severe and very severe group andthe control group (p<0.01).Conclusion: The results of the present study showed that auditory mechanisms may also be affected in patients with severe and very severe COPD.The authors of this study argue that necessary measures should be taken in the early stages of the disease for COPD patients to prevent the negativeeffects of chronic hypoxemia on the auditory system.
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    Nasal mucociliary clearance in obstructive sleep apnea syndrome patients
    (Ocean Side Publications Inc, 2014) Deniz, Mahmut; Gültekin, Erdoğan; Çiftçi, Zafer; Alp, Recep; Özdemir, Damla Nihan; Işık, Aklime; Demirel, Oral Burak
    Background: The main objective of this study was to investigate the correlation between the level of mucociliary dysfunction and severity of obstructive sleep apnea syndrome (OSAS). The effect of smoking in OSAS patients on mucociliary dysfunction was also assessed. Methods: It is a descriptive study that compares variables between groups (univariate analysis). In this clinical trial 122 patients with varying degrees of OSAS and 49 healthy volunteers were included (n = 171). Patients were divided into three groups as having mild, moderate, and severe OSAS, according to their apnea hypopnea index (AHI) values. (AHI values are typically categorized as 5-15/hr, mild OSAS; 15-30/hr, moderate OSAS; and >30/hr, severe OSAS.) The control group was comprised of healthy subjects. Each group was divided into smoking and nonsmoking subgroups. The mucociliary rates of the subjects were measured using the saccharin test. Statistical analysis was performed with the GraphPad Prism Version 3 pocket program. Results: Mild and moderate OSAS groups showed similar results with control group (p = 0.869), but severe OSAS patients showed a statistically significant difference with control group (Kruskal-Wallis [KW] = 32.28; p = 0.0032 and p < 0.05). Although in the moderate OSAS group the mucociliary clearance rates showed a tendency to decrease, this decrease was not significant (p = 0.453). A statistically significant difference was observed between smokers and nonsmokers in terms of mucociliary clearance times in all groups (KW = 18.24; p = 0.001). Conclusion: The nasal mucociliary system is significantly deteriorated in severe OSAS patients and they should be meticulously observed to prevent sinonasal infections. Measures to enhance mucociliary activity in these patients should be taken. Smoking, a well-known inhibitor of mucociliary activity, also has a negative impact on the mucociliary function of OSAS patients and quitting smoking would be of benefit for these patients.
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    The impact of different nasal packings on postoperative complications
    (W B Saunders Co-Elsevier Inc, 2014) Deniz, Mahmut; Çiftçi, Zafer; Işık, Aklime; Demirel, Oral Burak; Gültekin, Erdoğan
    Objective: The objective of this study was to find out if there is any association between the use of nasal packings and nasal synechia formation, septal perforation, postoperative infection and epistaxis in patients who underwent septoplasty and concha reduction operations. Methods: This retrospective study was conducted at a tertiary referral center. One hundred thirty patients were randomly selected among patients who underwent endonasal surgery in Narmik Kemal University Hospital between January 1st 2012 and August 1st 2013. Retrospective analysis of these patients' files, including operative reports and follow-up notes, was done. The postoperative findings of patients who had septal splints and Merocel nasal packings were compared and analyzed for statistical significance. Results: The results of the study showed a statistically significant difference in the frequency of synechia formation between two groups (p < 0.05). The frequency of synechia formation was found to be higher in the Merocel packing group. However, no statistically significant difference was found between groups in terms of postoperative infection, septal perforation, and epistaxis (p > 0.05). Conclusion: Our findings suggest that intranasal splints are superior to Merocel nasal packings in terms of preventing nasal synechia formation. Insertion of a septal splint after nasal surgery should be preferred to avoid this complication. On the other hand, other factors should be sought in the etiology of postoperative infection, septal perforation, and epistaxis. (C) 2014 Elsevier Inc. All rights reserved.
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    THE IMPLICATION OF THE PREOPERATIVE PLATELET TO LYMPHOCYTE RATIO IN THE DIAGNOSIS OF LARYNGEAL CARCINOMA
    (Namık Kemal Üniversitesi, Tıp Fakültesi, 2016) Ersözlü, Tolga; Demirel, Oral Burak
    Objectives: To investigate the diagnostic implication of the platelet to lymphocyte ratio (PLR) as a biological marker in predicting the malignancy of space-occupying laryngeal lesions. Methods: The medical records of the patients who underwent an operation for a laryngeal pathology between September 2010 and January 2015 in a tertiary referral center were retrospectively reviewed. For the control group, 50 age and sex matched patients were selected among the patients who underwent septoplasty. Preoperative platelet to lymphocyte ratio was calculated for each subject in the malignant, benign and control groups. Results: Comparison of the three groups using Kruskal Wallis test showed that there was no statistical difference between the groups. (p>0.05, p=0.871) The median PLR of the patients in the malignant group was lower than the benign group and the control group. Conclusions: In conclusion, squamous laryngeal carcinoma was not found to be associated with an increased preoperative PLR. Our findings indicated that, PLR may not be used as a biological marker for the diagnosis of laryngeal malignancy.