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    Cental Macular Thickness in Patients with Type 2 Diabetes Mellitus without Clinical Retinopathy
    (Hindawi Ltd, 2013) Demir, Mehmet; Dirim, Burcu; Acar, Zeynep; Yılmaz, Murat; Sendul, Yekta
    Objective. To compare central macular thickness (CMT) of diabetic patients with type 2 diabetes without clinical retinopathy and healthy subjects. Materials and Methods. Optical coherence tomography (OCT) measurements were performed in 124 eyes of 62 subjects with diabetes mellitus without clinical retinopathy (study group: 39 females, 23males; mean age: 55.06 +/- 9.77 years) and in 120 eyes of 60 healthy subjects (control group: 35 females, 25 males; mean age: 55.78 +/- 10.34 years). Blood biochemistry parameters were analyzed in all cases. The data for central macular thickness (at 1 mm), the levels of fasting plasma glucose, and glycosylated hemoglobin (HbA1c) were compared in both groups. Results. The mean central macular thickness was 232.12 +/- 24.41 mu m in the study group and 227.19 +/- 29.94 mu m in the control group. The mean HbA1c level was 8.92 +/- 2.58% in the study group and 5.07 +/- 0.70% in the control group (P = 0.001). No statistically significant relationship was found between CMT, HbA1c, and fasting plasma glucose level in either group (P > 0.05). Conclusions. Central macular thickness was not significantly thicker in patients with type 2 diabetes without clinical retinopathy than in healthy subjects.
  • Küçük Resim Yok
    Öğe
    Varfarin Doz Aşımına Bağlı Kanamalarda Hızlı ve Etkin Bir Tedavi Yöntemi: Plazma Kompleks Konsantresi
    (Acil Tıp Uzmanları Derneği, 2020) Örün, Serhat; Şahin, Hüseyin; Erdem, Mustafa; Bıçakcı, Sercan; Başol, Batuhan; Yeniay, Elif; Demir, Mehmet
    Introduction: Warfarin is important anticoagulant that we need in indications despite. Bleeding duo to overdose of warfarin can be lifethreatening when we don’t intervene early and correctly.Case report: A 81 years old female presented with weakness, anorexia and black colored defecating. She uses warfarin for 5 years because of prosthetic heart valve. On clinical examination she had hypotension and melena. Blood tests revealed Hemoglobin: 5,14 g/dl and INR:12,08. Vitamin K, Prothrombin complex concentrate and Proton pomp inhibitor was given as treatment in emergency service. The patient hospitalised in intensive care unit for further examination and treatment. Next day blood tests revealed Hemoglobin: 8,84 g/dl and INR:3,83.  The patient with no active bleeding focus on gastroscopy and with no decrease in hemoglobin tests discharged from hospital on 2nd day of hospitalization. Low-molecular-weight heparin treatment started.Discussion: Warfarin is a drug that still needed for treatment of atrial fibrillation, mechanical heart valves, protein c-s deficiency and antiphospholipid antibody disease. Common pathology of these diseases is predisposition to embolism and thrombus formation. In the emergency services, we need to make decisions according to the patient while treating patients who have warfarin overdose bleeding.  On the one hand to stop the bleeding to ensure the patient's hemodynamics, on the other hand, the risk of thromboembolism caused by the use of warfarin should not be ignored. Therefore, it is necessary to reduce the current INR level to the targeted INR level as quickly and safely as possible.Conclusion: In conclusion, we suggest that a timely and protocol-based approach to treat coagulapathy in patients with trauma and drug-induced coagulapathy may improve patients’ prognosis.