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    Caregiver Contribution to Self-care in Ostomy Patient Index: Turkish Validity and Reliability Study
    (Galenos Publ House, 2024) Yildiz, Tulin; Malak, Arzu; Erden, Dilek; Avcu, Cagla; Onler, Ebru; Duran, Yasin; Coskunkan, Ufuk
    Aim: This study was conducted to evaluate the Turkish validity and reliability of the Caregiver Contribution to Self-care in Ostomy Patient Index, to evaluate the relatives of patients with stoma who contributed to their self-care in Turkish society, and to contribute to the literature of the measurement tool. Materials and Methods: This methodological type of research was carried out between September 2020 and January 2021 in a state and a university hospital in Tekirda & gbreve;. The research sample consisted of 223 individuals who contributed to the self-care of individuals with colostomy, ileostomy and urostomy, who applied for outpatient control. In the analysis of the data, descriptive statistics, language and content validity, confirmatory factor analysis (CFA), item analysis, internal consistency and test-retest methods were used. Results: The Content Validity Index was 0.99 and Cronbach's alpha 0.890. According to the CFA, fit indices were within acceptable limits and all items were statistically significant in the 3 sub-dimensions of the scale. As in the original version of the scale, item 18, which was not statistically significant, was not included in the analysis and was accepted as an addition. The correlation between test-retest and scale items was 0.983 for the whole scale and between 0.973 and 0.987 for the sub-dimensions. Conclusion: At the end of the study, it was determined that the scale was suitable for Turkish society and was valid and reliable in Turkish.
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    Protective Effect of Nigella Sativa in an Animal Model of Colon Anastomosis With Ischemia/Reperfusion Injury
    (Int College Of Surgeons, 2018) Bali, İlhan; Polat, Fatin Rüştü; Aziret, Mehmet; Sözen, Selim; Oruc, Cem; Coskunkan, Ufuk; Koç, Ahmet; Bilir, Bülent; Emir, Seyfi
    Objective: Anastomotic leaks are one of the chief complications after gastrointestinal surgery. The aim of this study was to evaluate whether Nigella sativa administration protects against ischemia/reperfusion injury on healing of colonic anastomosis in rats. Method: Thirty male Wistar albino rats, weighing between 200 and 240 g, were used in the study. They were randomly divided into three groups (n = 10 for each group): Anastomosis (group 1), anastomosis and ischemia/reperfusion injury (group 2), and treatment group of anastomosis, ischemia/reperfusion injury, and Nigella sativa (group 3). After 7 days, serum, plasma, and colonic tissue were obtained and then all rats were sacrificed. Tissue and serum level of total oxidant status, total antioxidant status, total thiol levels, hydroxyproline, interleukin-6, and TNF-alpha were determined and specimens were histopathologically evaluated. Results: In the Nigella sativa treated rats, serum hydroxyproline levels were significantly higher, while tissue levels were significantly lower than those seen in group 1 and group 2 (P = 0.007, P = 0.01, respectively). In the Nigella sativa group, the serum levels of TNF-alpha were significantly lower than those seen in group 1 and 2 (P = 0.001). Also, in group 3, the tissue IL-6 level was significantly higher than that seen in group 1 and group 2 (P = 0.009). The histopathologic analysis showed less edema and inflammatory cell infiltration in the Nigella sativa treated group, as well as a statistically significant difference according to the Chiu classification (P < 0.05). Conclusion: The results of this study indicate that Nigella sativa has a protective and therapeutic effect against ischemia/reperfusion injury on the healing of colonic anastomosis in rats.