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    Association of selenoprotein W1 (rs3786777) polymorphism, maternal plasma selenoprotein W (SelW), and selenium levels in patients with pre-eclampsia
    (Dustri-Verlag Dr Karl Feistle, 2019) Cinemre, Fatma Behice Serinkan; Cinemre, Hakan; Erdoğan, Elif; Dilaveroğlu, Nilgün; Tüten, Abdullah; Kaya, Baris; Aydemir, Birsen; Kızıler, Ali Rıza
    Objective: To investigate the role of selenoprotein W1 (SEPW1) single nucleotide polymorphism (SNP) in etiopathogenesis of pre-eclampsia (PE) and its association with maternal selenoprotein W (SelW) and selenium levels. Materials and methods: In this study, 98 pregnant women who were diagnosed with PE and 100 healthy pregnant controls were investigated. To identify the polymorphism of the SEPW1 gene (rs3786777), allele-specific polymerase chain reaction (ASPCR) analysis was used. Serum selenium levels and plasma SelW levels were measured by graphite-furnace atomic absorption spectrophotometry and by ELISA, respectively. Results: Maternal selenium levels (mu g/L) were 92.56 +/- 6.10 and 86.26 +/- 6.33 in pregnant women with and without PE, respectively (p > 0.05). On the other hand, SelW levels (ng/mL) were significantly lower in PE (72.08 +/- 8.10) compared to controls (89.29 +/- 6.99) (p < 0.01). The frequencies of the CC, CA, and AA genotypes were found to be 26%, 61%, and 13% in pregnant women with PE and 28%, 55%, and 17% in healthy pregnant controls. The distribution of the SEPW1 genotypes and alleles did not differ significantly among subjects with and without PE. In PE patients, SelW levels were lower in CC and CA genotypes compared to controls (p < 0.05 and p < 0.001). Conclusion: SEPW1 gene polymorphism did not seem to affect risk of PE in our population. However, SelW levels were low in some genotypes of the gene, suggesting that SelW might have played a role in the etiopathogenesis of PE.
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    Evaluation of metallothionein-1, metallothionein-2, lipid peroxidation and trace elements status in the progression of the spontaneous mitral chordae tendineae rupture patients
    (Dustri-Verlag Dr Karl Feistle, 2016) Aydemir, Birsen; Cinemre, Fatma Behice Serinkan; Cinemre, Hakan; Kızıler, Ali Rıza; Akdemir, Ramazan; Vatan, Mehmet Bülent; Akkoyun, Dursun Çayan
    Objective: The aim of the present study was to investigate whether copper, zinc and iron levels and copper/zinc, iron/zinc, iron/copper ratios in serum and erythrocytes are associated with lipid oxidation levels, metallothionein-1 (MT-1), and metallothionein-2 (MT-2) levels in plasma in the context of pathogenesis of the mitral chordae tendineae rupture (MCTR). Methods: 65 subjects who were identical in demographic characteristics' were selected for the study; 33 with MCTR patients, and 32 healthy control subjects. The levels of MT-1, MT-2, and malondialdehyde as measure of lipid oxidation, and trace elements were determined by enzyme-linked immunosorbent assay, spectrophotometric method, and inductively coupled plasma optical emission spectrometry, respectively. Results: Serum zinc levels were found to be lower in the patients' group when compared to control group. The copper and iron levels in serum, MT-1, MT-2; malondialdehyde levels in plasma, iron and malondialdehyde levels in erythrocytes; serum copper/zinc and iron/zinc ratios were found to be higher in the patients' group when compared to controls. Conclusions: We conclude that the changes of oxidant antioxidant system balance and trace element status may contribute to the etiopathogenesis of MCTR.
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    LOX-1 gene variants and maternal levels of plasma oxidized LDL and malondialdehyde in patients with gestational diabetes mellitus
    (Springer Heidelberg, 2016) Aydemir, Birsen; Baykara, Onur; Cinemre, Fatma Behice Serinkan; Cinemre, Hakan; Tüten, Abdullah; Kızıler, Ali Rıza; Uzun, Hafize
    Purpose The aim of this study was to investigate the relationships between the maternal levels of oxidized LDL (ox-LDL), lipid peroxidation marker malondialdehyde (MDA) and LOX-1 3'UTR188C/T and K167N single nucleotide polymorphisms in pregnant Turkish women with gestational diabetes mellitus (GDM). Methods 116 pregnant women with GDM and 120 healthy pregnant women from the same geographic region were included in the study. Polymerase chain reaction-based restriction analysis was used to identify 3'UTR188C/T and K167N polymorphisms of the LOX-1 gene. Plasma ox-LDL and MDA levels were determined by enzyme-linked immunosorbent assay and spectrophotometric method in all study subjects, respectively. Results Our results indicated that the distribution of the LOX-1 3'UTR188C/T and K167N genotypes and alleles did not differ significantly among subjects with or without GDM (p> 0.05). TT and NN genotype carriers are associated with some glucose metabolism parameters (p< 0.05). There were no significant differences among plasma ox-LDL and MDA levels with regard to LOX-1 3'UTR188C/T and K167N polymorphisms in GDM group and control subjects (p> 0.05). According to the combined genotype analysis of LOX-1 3'UTR 188 TT and K167N NN polymorphisms, plasma MDA and ox-LDL levels were significantly different between women with GDM and healthy subjects either with or without combined TT/NN genotype carriers (p< 0.001). Conclusions According to our results, ox-LDL and MDA levels were increased in GDM pregnant women and healthy pregnant women either with or without combined TT/NN genotype carriers, for our Turkish sample, these genotype carriers appear to be related with increased oxidative stress in patients with GDM.
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    Midkine Levels and its Relationship with Atherosclerotic Risk Factors in Essential Hypertensive Patients
    (Wolters Kluwer Medknow Publications, 2018) Güzel, Savaş; Cinemre, Fatma Behice Serinkan; Güzel, Eda Çelik; Küçükyalçın, Volkan; Kızıler, Ali Rıza; Çavuşoğlu, Coşkun; Aydemir, Birsen
    Background and Objectives: Hypertension (HT) is one of the risk factors associated with atherosclerosis. Midkine (MK) plays a role as a growth factor in various biologic and pathologic events. In some reports, MK expression has been shown to be linked with vascular smooth muscle proliferation and neo-angiogenesis in atherosclerotic vessels. The aim was to research relationship of MK serum levels with some atherosclerotic risk factors in hypertensive patients. Methodology: This study examined 60 patients with essential HT and 30 healthy controls. Serum biochemistry, including lipid profile, MK, Vitamin B 12, C-reactive protein, zinc and copper levels were obtained. Results: MK levels of the HT patients were significantly higher than the control group (24.8 +/- 6.8 ng/mL vs. 18.39 +/- 5.6 ng/mL, respectively, P < 0.01). Lipid profile parameters such as total cholesterol, triglyceride, low-density lipoprotein (LDL) were also significantly higher in HT patients (P < 0.021, P < 0.01, and P < 0.01, respectively). Zinc levels were 179.13 +/- 34.06 mu g/dL and 172.55 +/- 45.47 mu g/dL in the HT and control group, respectively. Serum MK levels were positively correlated with diastolic (r = 0.288, P < 0.05) and systolic blood pressures (r = 0.390, P < 0.002), and also with serum total cholesterol (r = 0.406, P < 0.002) and LDL cholesterol (r = 0.318, P < 0.015) levels. Furthermore MK was also negatively correlated with zinc and Vitamin B 12 levels (r = -0.298, P < 0.023, r = -0.334, P < 0.027, respectively). Conclusion: This study has demonstrated an important association between increased serum MK levels and risk factors of atherosclerosis such as HT, increased total and LDL cholesterol.
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    The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture
    (Humana Press Inc, 2015) Aydemir, Birsen; Akdemir, Ramazan; Vatan, M. Bülent; Cinemre, Fatma Behice Serinkan; Cinemre, Hakan; Kızıler, Ali Rıza; Öğut, Selim
    Chordae tendineae rupture process is associated with increased production of inflammatory and angiogenesis mediators in connective tissues, which contributes to chronic inflammation and pathogenesis of degenerative chordae. A few trace elements are known to possess antioxidant, anti-inflammatory, and antiangiogenic properties. Therefore, the aim of this study was to determine whether zinc, selenium, midkine (MK), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), vascular endothelial growth factor-A (VEGF-A), platelet-derived growth factor-BB (PDGF-BB), and reduced glutathione (GSH) levels are associated with inflammation and angiogenesis processes in the context of a potential etiology causing aggravation of mitral regurgitation and/or ruptured chordae tendineae. Seventy-one subjects comprising 34 patients with mitral chordae tendineae rupture (MCTR) and 37 healthy controls diagnosed on the basis of their clinical profile and transthoracic echocardiography were included in this study. The levels of GSH, MK, selenium, and zinc were found to be lower in the patients group when compared to control group. There were no significant difference in plasma TNF-alpha, IL-1 beta, IL-6, IL-8, VEGF-A, and PDGF-BB levels between two groups. There were positive significant correlations between MK and GSH, MK, and selenium levels in patients with MCTR. According to our data in which selenium, zinc, MK, and GSH decreased in MCTR patients, inflammatory response, oxidative stress, and trace element levels may contribute to etiopathogenesis of mitral regurgitation and/or ruptured chordae tendineae.
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    The role of selenoprotein P and selenium in the etiopathogenesis of gestational diabetes mellitus: Association with selenoprotein P1 gene (rs3877899) polymorphism
    (Dustri-Verlag Dr Karl Feistle, 2018) Cinemre, Fatma Behice Serinkan; Cinemre, Hakan; Yücel, Ayse; Değirmencioğlu, Sevgin; Tüten, Abdullah; Yüksel, M. Aytac; Aydemir, Birsen; Kızıler, Ali Rıza
    Objective: The aim of this study was to investigate the role of selenoprotein P (SeP) and selenium in the etiopathogenesis of gestational diabetes mellitus (GDM) and their association with a common selenoprotein P1 (rs3877899) single nucleotide polymorphism (SNP) in pregnant women with GDM. Materials and methods: Eighty-six pregnant women with GDM and 90 healthy pregnant women from the same geographic region were included in the study. Fasting glucose, insulin HOMA-IR, and HbA1c were compared. Serum selenium levels were measured by graphite-furnace atomic absorption spectrophotometer. Plasma SeP levels were determined by ELISA. Allele-specific polymerase chain reaction (ASPCR) analysis was used to identify polymorphisms of the selenoprotein P1 gene (SEPP1) (rs3877899). Results: The biochemical parameters of GDM such as fasting glucose, insulin, HOMA-IR, and HbA1c were higher in pregnant women with GDM compared to healthy pregnant women. Maternal selenium levels (mu g/L) were 77.99 +/- 7.21 and 76.04 +/- 7.77 in GDM and healthy pregnant women, respectively (p > 0.05). However, SeP levels (ng/mL) were found to be significantly lower in GDM (35.29 +/- 3.00) compared to control subjects (46.98 +/- 4.59) (p < 0.01). Although there was no significant difference in the distribution of the SEPP1 genotypes and alleles between two groups, SeP levels were higher in the GG genotype of the gene compared to their respective control (p < 0.001). Conclusion: Although frequency of SEPP1 polymorphism and selenium levels did not differ significantly between diabetic and healthy pregnant women, SeP levels increased in pregnant women with GDM suggesting SeP plays a role in the etiopathogenesis of GDM. Moreover, the GG genotype of SEPP1 gene polymorphism may be involved in the development of GDM with a different mechanism. It should be clarified with further studies in larger populations.
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    Thyroid Dysfunctions Due to Lithium Treatment in Bipolar Disorder: Changes in Oxidative Stress, Trace Elements, and Hemorheological Parameters
    (Polish Society Magnesium Research, 2020) Bahtiyar, Nurten; Cinemre, Fatma Behice Serinkan; Cinemre, Hakan; Kızıler, Ali Rıza; Atagün, Murat İlhan; Gulyasar, Tevfik; Aydemir, Birsen
    Lithium is one of the most widely used medications for the treatment of bipolar disorder (BD). It also has some side effects on thyroid functions. We aimed to investigate the role of oxidative stress, trace elements, and hemorheological parameters on the pathophysiology of thyroid dysfunctions developed by lithium treatment in patients with BD. Patients with BD were divided into three groups: patients that non-lithium-treated, lithium-treated patients for 4-6 weeks, and lithium-treated patients for 40-68 weeks. Blood samples for analysis were taken before and after the treatment period. After analysis, patients were divided into six groups: non-treatment BD group (Group 1); short-term lithium-treatment group that did not develop thyroid dysfunctions (Group 2); short-term lithium-treatment group that developed hyperthyroidism (Group 3); long-term lithium treatment group that developed hypothyroidism (Group 4), long-term lithium-treatment group that developed hyperthyroidism (Group 5), and long-term lithium-treatment group that did not develop thyroid dysfunctions (Group 6). Plasma and whole blood viscosity levels were significantly increased in Groups 4 and 6 compared to Groups 1, 2, and 3. Hemoglobin levels were lower in Group 4 than in Groups 1, 2, and 5. Fibrinogen values were higher in Groups 4 and 5 than Group 1. Plasma and erythrocyte malondialdehyde levels were higher in Group 4 than In Groups 1, 2, 3, and 5. Also, they were increased in Group 6 in comparison with Groups 2 and 3. Erythrocyte glutathione levels were lower in Groups 4 and 6 than Groups 1, 2, 3 and 5. Plasma protein carbonyls levels were higher in Group 4 than in Group 1, or in Group 5 than in Groups 1, 2, and 3, as well as in Group 6 than Groups 1, and 2. Serum zinc levels were higher in Groups 2, 3 and 6 than in Group1. Serum copper levels increased in Groups 2, 4 and 6 in comparison with Group1. The results of this study indicate that oxidative stress increased with treatment time in lithium-induced thyroid dysfunctions. Also, whole blood viscosity, plasma viscosity, fibrinogen, zinc, and copper levels were affected by lithium treatment and treatment duration induced thyroid dysfunctions.