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    Cytological features of pure micropapillary carcinoma of various organs: A report of eight cases
    (Spandidos Publ Ltd, 2014) Huq, Gülben Erdem; Canberk, Sule; Öznur, Meltem; Yıldız, Pelin; Bahadir, Burak; Behzatoğlu, Kemal
    Micropapillary carcinoma (MPC) is a rare aggressive tumor, which generally accompanies the primary carcinoma of the organ of its origin, while the pure form is extremely uncommon. Angiolymphatic involvement is widespread and a considerable proportion of the cases present with metastases. The current study presents eight pure MPC cases arising from the breast (n=3), urinary bladder (n=3), parotid gland (n=1) and lung (n=1, presenting with pericardial effusion), with the cytological findings. The eight patients included three female and five male cases aged between 48 and 74 years. The most common cytological findings were three-dimensional aggregates, cell clusters with angulated or scalloped borders, single cells with a columnar configuration and eccentric nuclei, and high-grade nuclear features. Histopathological sections showed accompanying in situ ductal carcinoma in the cases of MPC arising in the parotid gland and breast (n=3), and one case in the bladder exhibited only in situ MPC. The average follow-up period was 20 months (range, 6-54 months) and, during this period, three patients succumbed to the disease. At present, four patients are alive with disease and one patient is alive and disease-free. In conclusion, cytology is an important tool for the diagnosis and management of MPC.
  • Küçük Resim
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    The Correlation of CD24 Expression with Tumor Stage and Grade in Urothelial Carcinomas of the Urinary Bladder
    (Istanbul Training & Research Hospital, 2013) Canberk, Sule; Hak, Gülben Erdem; Öznur, Meltem; Behzatoğlu, Kemal; Bozkurt, Erol Rüştü
    Objective: Initially, CD24 was idendified as a B cell marker, in addition to a role of CD24 for the intracellular signaling, and it is also participates in the regulation of cell to cell and cell to matrix interactions. CD24 has been implicated in the progression of several types of cancer and has been identified as a prognostic factor in the last 10 years. We focused our attention on possible associations between CD24 expression and stage-grade of tumors in bladder urothelial carcinoma as important morphologic-prognostic paramaters. Methods: A total of 79 patients with bladder urothelial carcinomas were included in this study and these 79 patients underwent transurothelial resection biopsy at the Istanbul Education and research Hospital between 2005-2008. Hematoxylin-eosin stained sections from each case were reevaluated histopathologically according to the WHO-2004 grading system. The TNM system was used for pathologic staging. Selected slides were also studied by immunohistochemistry and a semiquantitative scoring for CD24 expression based on the percentage of positive cells was performed. Results: We found that CD24 expression was associated with invasive (pT1-2) and noninvasive (pTa) tumors. Normal urothelial epithelium and the adjacent non neoplastic urothelium in cancer specimens demostrated weak immunreactivity for CD24 and well-confined localization in the apical cytoplasm or apical membranes (Score 0-1). The most distinctive feature of CD24 expression was that the invasive cancer cells lost the apical polarity of CD24. The invasive cancer cells showed a nonpolarized cytoplasmic staining for CD24. The stage pTa tumor cells displayed weak staining in CD24 expression and most staining showed on apical localization. Conclusion: This study provides the basis of future investigations of CD24 as a potential serum marker or target of antibody-based therapeutics in bladder urothelial carcinoma.