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Öğe Brown Tumors: A Case Report and Review of the Literature(Karger, 2016) Can, Ozgur; Boynueğri, Başak; Gökçe, Ali Murat; Özdemir, Ebru; Ferhatoglu, Ferhat; Canbakan, Mustafa; Apaydın, Süheyla; Titiz, Mesut İzzetBrown tumors are focal bone lesions, encountered in patients with uncontrolled hyperparathyroidism. They can be located in any part of the skeleton. Clinically significant lesions in the craniofacial bones are rare. Craniofacial involvement may cause facial disfiguration and compromise social ease of the patient and normal functions, such as chewing, talking, and breathing. In this case report, we present a patient with a brown tumor of the craniofacial bones provoked by secondary hyperparathyroidism and review the last 10 years of craniofacial brown tumors associated with secondary hyperparathyroidism in the English literature. (C) 2016 The Author(s) Published by S. Karger AG, BaselÖğe Evaluation of Pre-Transplant Panel Reactive Antibody Levels and Sensitization: A Single-Center Study(Int Scientific Literature, Inc, 2016) Can, Ozgur; Gökçe, Ali Murat; Canbakan, Mustafa; Ata, Pınar; Şahin, Gülizar Manga; Titiz, Mesut İzzet; Apaydın, SüheylaBackground: Sensitization is one of the most important barriers against transplantation. Our aim was to evaluate the sensitization status of our patients awaiting cadaveric transplantation and to identify factors causing sensitization. Material/Methods: A total of 140 patients on the cadaveric waiting list during January 2014 were included in this retrospective cross-sectional study. The parametric t-test and the non-parametric chi-square test were used to detect differences between PRA-positive and -negative patients. Multivariate analysis was used to identify factors associated with PRA positivity. One-way analysis of variance was used to compare PRA-negative and -positive results. Results: Anti-HCV positivity (p=0.040), history of transfusion (p=0.041), and mean number of blood product transfused (p=0.047) were significantly related to class 1 PRA positivity. History of transfusion (p=0.038) and mean number of blood product transfused (p=0.044) were related to class 2 PRA positivity. The multivariate analysis indicated that transfusion and more than 5 units of blood product transfused were related to either class 1 or class 2 PRA positivity. No associations were found between PRA positivity and pregnancy, transplantation, age, sex, infection, abortion, cardiovascular disease, diabetes mellitus, hepatitis B, or time spent on dialysis and being on the transplantation waiting list. Conclusions: Anti-HCV positivity and transfusion are risk factors for sensitization. Particular emphasis should be given to sensitization and its prevention to reduce waiting time for transplantation.