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    Does COVID-19 reduce anti-Mullerian hormone levels in women of reproductive age in late periods of infection?
    (Galenos Publ House, 2024) Dogan, Keziban; Kural, Alev; Aslan, Ilke Ozer; Erdogan, Aliye; Gonul, Mazlum; Dura, Mustafa Cengiz; Helvaci, Nazli
    Objective: The question of whether severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection influences ovarian function and oocyte quality has arisen as angiotensin converting enzyme-2 receptors, which facilitates viral infection, are found on reproductive system tissues, including the vagina, placenta, uterus, and ovaries. The primary objective of this prospective study was to evaluate the impact of SARSCoV-2, on ovarian function, with a focus on anti-Mullerian hormone (AMH) and acute phase reactant levels in patients well after recovery from coronavirus disease-2019 (COVID-19). Material and Methods: This prospective cohort study was conducted in the department of obstetrics and gynecology at a single center between October 2020 and June 2021. In order to investigate the impact of COVID-19 on ovarian reserve, 34 non-pregnant women of reproductive age (24-38 years) with COVID-19 polymerase chain reaction positivity were included. Results: The difference between AMH levels measured 6 months after COVID-19 infection and baseline AMH levels was-0.31 +/- 0.80 ng/dL on average and-0.25 (-2.1-1.3) ng/dL on median. Significant correlations were observed between the change in AMH levels and white blood cell levels (r=-0.434, p=0.010), lymphocyte levels (r=-0.361, p=0.036), C-reactive protein levels (r=0.542, p=0.001), ferritin levels (r=0.570, p=0.001) and procalcitonin levels (r=0.598, p=0.001). Conclusion: We believe this is the first study to examine whether there is a correlation between the late results of COVID-19 and ovarian function. In this cohort, AMH values decreased 6-months after recovery from COVID-19 and a correlation was found between measures of disease severity and the magnitude of decrease in AMH. However, the study was underpowered and future larger studies are required to validate these findings. (J Turk Ger Gynecol Assoc. 2024; 25: 231-7)
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    Evaluation of the incidence of anomaly in fetus and neonates of prenatal aneuploidy screening
    (Bayrakol Medical Publisher, 2024) Demir, Salih; Aslan, Mustafa Torehan; Aslan, Ilke Ozer
    Aim: Our study aimed to investigate the frequency of anomalies and related maternal and neonatal outcomes in pregnant women who were admitted in our clinic in the last five years and underwent prenatal aneuploidy screening. Materials and Methods: The prenatal fetal aneuploidy screening results of the pregnant women who participated in the study, the pregnant and maternal outcomes of the pregnant women who underwent amniocentesis according to these results, and the detection rates of chromosomal aneuploidy in infants were retrospectively analyzed. Results: According to the first -trimester screening test, 22.4% of the cases (n=121); According to the second -trimester screening test, 11.8% (n=6) of the patients were found to be at high risk for chromosomal aneuploidy. Amniocentesis was recommended to 199 participating in the study, and 17.6% (n=35) of these cases were accepted. Chromosomal aneuploidy was found in 1.8% (n=3) of those who underwent amniocentesis. Two pregnancies with aneuploidy were terminated at the request of the families. The anxiety levels of the pregnant women who had prenatal screening tests were higher in the studies. Discussion: Fetal aneuploidy screening tests may give false positive results at high rates, adversely affecting maternal anxiety and, thus, pregnancy outcomes. To increase the prenatal diagnosis rates cost-effectively, it is helpful to perform combined tests to increase the sensitivity or more sensitive tests are needed.
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    EZH2 expression in the skin of developing human fetuses and adults: a comparative study
    (Cukurova Univ, Fac Medicine, 2023) Zorlu, Ozge; Karabag, Sevil; Erdogan, Kivilcim Eren; Kussever, Evin; Aslan, Ilke Ozer
    Purpose: In animals, the appropriate levels of Enhancer of zeste homolog 2 (EZH2), a well-established epigenetic regulator, are essential for the embryonic development of skin and appendages. We aimed to explore the EZH2 expression patterns in the skin of human fetuses and compare them with adults.Materials and Methods: We performed EZH2 immunohistochemical staining in skin samples from the scalp region of 67 fetuses and from the farthest surgical margin of the lip wedge resection, where no lesions were found, of 23 adults. EZH2 scores were evaluated according to the literature.Results: Epidermal (r = - 0.528), dermal (rs = - 0.509), and hair follicle (r = - 0.576) EZH2 scores were inversely correlated with gestational age. Epidermal and hair follicle EZH2 scores were significantly higher in adults compared to fetuses. There were significant and positive correlations between epidermal, dermal, and hair follicle EZH2 scores among fetuses and adults.Conclusion: Lower levels of EZH2 may be necessary for final cutaneous differentiation and maturation before birth. Our findings may have a therapeutic impact on cutaneous disorders with differentiation defects, chronic wounds, and alopecias.
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    The effect of informing the patient about the procedure with video imaging before office hysteroscopy on pain
    (Wiley, 2023) Callioglu, Nihal; Gul, Derya Kanza; Aslan, Ilke Ozer; Tunca, Aysun Fendal; Kasim, Kardelen Basli; Akay, Burcu; Uysal, Elif
    Objective: To evaluate the effect of informing patients undergoing diagnostic office hysteroscopy via a video 24 h before the procedure and determine the changes in pain scores, channel transit time, the degree of difficulty of the procedure, and physiological parameters. Design: Single-blind randomized controlled trial. Setting: The study was conducted between September 1, 2021 and April 1, 2022 at the University of Health Sciences Bakirkoy Dr. Sadi Konuk Training and Research Hospital. Participants: A total of 134 patients aged 18-65 years who needed diagnostic office hysteroscopy. Interventions: Participants were randomized into two groups, the standard information group (Group 1: controls), and the video information + standard information group (Group 2). After office hysteroscopy, a visual analog scale (VAS) and Likert scale were used to assess pain and the degree of difficulty of the procedure, respectively. Physiological parameters were evaluated before and after the procedure. Main Outcome Measure: To determine the effect of video-based multimedia information administered 24 h before office hysteroscopy on post-procedure pain. Results: The mean VAS score of the group that watched the training video (3.02 +/- 1.88) was significantly lower than the control group (4.72 +/- 2.54) who did not watch the training video (p < 0.001). The mean cervical channel transit time in seconds (sec) during the procedure was found to be significantly higher in the control group (21.57 +/- 15.10 s) than in the video-watching group (p = 0.011). There was no significant difference between the groups in terms of physiological parameters and the degree of ease of the procedure. Conclusion: Our study has shown that informing patients in a pre-procedure video is an effective approach that shortens the duration of the channel transit time and reduces pain.
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    The effect of stress incontinence and pelvic organ prolapse surgery on sexual function and quality of life
    (Galenos Publ House, 2024) Dogan, Keziban; Oztoprak, Mustafa Yasin; Dura, Mustafa Cengiz; Aslan, Ilke Ozer
    Objective: The objective of this study was to evaluate the sexual function and quality of life in female patients diagnosed with stress urinary incontinence (SUI) and pelvic organ prolapse (POP) after undergoing transobturator tape (TOT) or TOT with POP surgery and perineoplasty. Material and Methods: This prospective study population (n=86) consisted of sexually active women who had been diagnosed with SUI. Forty-six patients diagnosed with SUI with no POP (group 1) underwent TOT procedure only. Forty patients had a diagnosis of stage 2 and higher POP, based on POP quantification system with SUI (group 2). The second group was randomized as TOT -POP surgery (n=20) and TOT -POP surgery with perineoplasty (n=20). Prior to and six months after the surgical procedure, all female participants underwent assessment using the validated Urinary Distress Pre -Operative Inventory (UDI-6), Incontinence Impact Questionnaire (IIQ-7), and Pelvic Organ Prolapse Incontinence Sexual Questionnaire (PISQ). Results: Post -operative IIQ-7 and UDI-6 scores were significantly lower for all three groups compared to the preoperative period, while a significant increase was observed in PISQ scores (p<0.01). The dissimilarity in preoperative and postoperative IIQ-7 and UDI-6 scores exhibited comparable results across the groups, whereas the variance in PISQ scores was notably greater in the TOT + POP surgery + perineoplasty group (p=0.03). Conclusion: Women with SUI or SUI with POP have better quality of life and sexual dysfunction after surgery. Perineoplasty may enhance sexual life in patients with perineal defect and vaginal enlargement.
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    Top cited articles about the stress urinary incontinence: A bibliometric analysis
    (Elsevier, 2024) Aslan, Ilke Ozer; Dogan, Cagri
    Objective: To produce a bibliographic source by compiling the most-cited articles about stress urinary incontinence to guide researchers for novel research topic ideas in urogynecology. Study design: We analyzed 200 most-cited articles (T200) between 1995-2022 by reviewing the Institution for Scientific Information (ISI)- Web of Science (WOS) and PubMed databases about the stress urinary incontinence. The time span-effect of publications was normalized by calculating average citations per item (ACI) index for each article. The publications were sub-classified by the publication year, journals, countries, surgical methods, and departments. Results: The median for total citation numbers and the ACI indices of T200 were 35 and 5 respectively. The top- cited articles were mostly published in USA with 91 articles (46.5 %) followed by Italy (22, 11 %), and United Kingdom (21, 10.5 %). Among T200, 149 were original research, 44 reviews, 4 meta-analyses, and 3 editorial articles. Further, 59 were about surgical procedures (of which 28 were about TOT-TVT comparison). M. Serati and L. Bruker were the most contributing authors to T200 with 19 articles. On the top of T200, the article of Pierre A. Clavien et al . (2009) sits with 6201 citations, published in the journal of Annals of Surgery. Conclusions: We suggest that the most-cited articles commonly conducted in the high-income countries, mostly published between 2014-2018. Best of our knowledge, this is the first study analyzing the most-cited 200 publications in urogynecology field under two different perspectives of two different disciplines, namely urology and obstetrics and gynecology.