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Öğe Assessment of the Relationship between Vitamin D Deficiency and the Development of Hyperemesis Gravidarum(Ordu University, 2023) Çetinkaya, Osman Eren; Aslan, İlke Özer; Kural, Alev; Doğan, KezibanObject: Hyperemesis gravidarum, the leading cause of hospitalization in the first trimester, is observed in 0.3% to 3.6% of all pregnant women worldwide. Vitamin D is a significant vitamin for human health, and vitamin D deficiency in the pregnant women population in Turkey is a common pathology. In this context, this study was carried out to assess the relationship between vitamin D deficiency and the development of hyperemesis gravidarum. Methods: The population of this prospective, single-center, case-controlled study consisted of pregnant women diagnosed with hyperemesis gravidarum. In the end, 23 pregnant women with hyperemesis gravidarum were included in the patient group, and 30 healthy pregnant women with demographic characteristics that match those with hyperemesis gravidarum were included in the control group. The Vitamin D and hematocrit levels were compared between the two groups. Results: There was no significant difference between the patient and control groups in the serum vitamin D (p = 0.760) and hematocrit (p = 0.149) levels. Overall, only 9 (17%) of the 53 pregnant women had sufficient (> 20 ng / ml) vitamin D. There was no significant difference between the patient and control groups in the number of patients with vitamin D deficiency. Conclusion: The study findings did not indicate a correlation between vitamin D deficiency and hyperemesis gravidarum. Further large-scale studies are needed to establish the absence of a relationship between vitamin D deficiency and hyperemesis gravidarum. On the other hand, the fact that only 17% of the pregnant women who participated in this study had sufficient vitamin D revealed the need to emphasize using vitamin D supplements in pregnant women as early as possible in the first trimester.Öğe Evaluation of Sexual Function of Women with Primary Sjogren’s Syndrome and Investigation of the Effects of Lubricants on Sexual Drive(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Çallıoğlu, Nihal; Baghaki, Sema; Zirtiloglu, Sibel; Yüksel, Semra; Doğan, Keziban; Aslan, İlke ÖzerPrimary Sjogren's syndrome (pSS) is a chronic autoimmune disease that causes vaginal dryness and dyspareunia secondary to lymphocytic infiltration of exocrine glands. This study aimed to evaluate the sexual functions of premenopausal and postmenopausal women with pSS and to investigate the effects of using polycarbophil-containing vaginal moisturizing gel on sexual function. The study included 24 female patients (mean age 45.1 ± 6.1, range 33 to 54 years) with pSS, who had an active sex life and reported vaginal dryness. The patients were asked to use 1 g of polycarbophil-containing vaginal gel twice per week for 12 weeks. Patients were assessed using the Female Sexual Function Index (FSFI) and Beck Depression Inventory (BDI) before and after vaginal lubricant use. All patients underwent full gynecologic examinations. After treatment with vaginal lubricants, significant improvements were observed in the lubrication scores, satisfaction, and pain during intercourse (p=0.032, p=0.002, and p=0.006, respectively). The total post-treatment FSFI score was detected to be higher than the values of pre-treatment [median 22.5 (range, 15.1-32.4) vs. 20 (range, 12.3-28.5), respectively; p=0.004]. Considering the sum and sub-parameters of FSFI in postmenopausal women before and after lubricant treatment, there were significant differences in premenopausal satisfaction, pain reviews, and total FSFI scores (p=0.014, p=0.014, and p=0.032, respectively). The use of polycarbophil-containing vaginal moisturizing gel improved sexual symptoms in women with Sjogren's syndrome, especially in the premenopausal period, without serious adverse effects; therefore, we concluded that non-hormonal polycarbophil-based gel could be used in the treatment of patients with this condition. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Öğe Knowledge Level Assessment Survey of Nurses at Tekırdag Namik Kemal University Medical Research Center, About HPV Vaccination(Tekirdağ Namık Kemal Üniversitesi, 2018) Satılmışoğlu, Zeliha Zeynep; Aslan, İlke Özer; Can, Nebibe; Gülcivan, Gülbahar; Yıldız, Tülin; Şentürk, MehmetbakiAbstract Aim: Cervical cancer is a common and mostly fatal gynecological malignancy. HPV vaccination is a secure and efficient procedure to prevent cancer before the first sexual intercourse. Designed to prevent the majority of invasive cervical cancer, quadrivalent (HPV 6/11/16/18) and bivalent (HPV 16/18) vaccines have been available since 2006 and 2007. These vaccines can prevent most cases of cervical cancer if given before a girl or woman is exposed to the virus. The Advisory Committee on Immunization Practices- ACIP suggests that girls should be vaccinated around the age of 12 years, even series can be started at age of 9 years. Material and Method: Between the dates of 1 January – 28 February 2018 at Tekirdağ Namık Kemal University Medical Research Center 50 nurses who have daughters, answered the questions of knowledge level assesstment survey about HPV vaccination. Results: Although %88 of the nurses know how and why to screen cervical cancer, only %32 of them had regular gynecological examination and cervical cancer screening. The rate of informing patients about HPV vaccination at gynecologist appointments of these 50 nurses, is %15. Conclusion: Nurses, providing healthcare services and health education to the community, have sufficient knowledge about HPV vaccination, which is indispensable for preventing cervical cancer. However, their trust in HPV vaccines is at very low levels. Additionally, our research shows that gynecologists cannot inform their patients efficiently due to not having HPV vaccination on National Immunizations Programme and additional costs. Key words: Vaccine, HPV, cervix cancer.Öğe PREMALİGN SERVİKOVAGİNAL SMEAR SONUÇLARININ KOLPOSKOPİ VE LEEP İLE KORELASYONU(2020) Aslan, İlke Özer; Satılmışoğlu, Zeliha Zeynep; Aksu, ErsonAmaç: Bu çalışmada, serviks kanseri taramasında smear, kolposkopi ve LEEP/konizasyon aşamalarından geçen hastaların patoloji sonuçlarını değerlendirilerek birbirleri arasındaki uyumluluk derecesini incelemek ve tedavi sonuçlarını değerlendirebilmek amaçlandı.Materyal ve Metot: Ocak 2010-Aralık 2017 tarihleri arasında Namık Kemal Üniversitesi Kadın Hastalıkları ve Doğum polikliniğine başvuran LEEP işlemi uygulanmış 145 hasta çalışmaya dahil edildi. Bu hastaların LEEP, kolposkopik biyopsi ve smear patoloji sonuçları arasındaki uyumluluk dereceleri retrospektif olarak incelendi. İstatistiksel analizler için İstatistiksel analizler için NCSS (Number Cruncher Statistical System) 2007 (Kaysville, Utah, USA) programı kullanıldı.Bulgular: HPV DNA sonucu pozitif olup LEEP ve kolposkopi yapılan hastaların patoloji sonuçları incelendiğinde %62.9’unda CIN 2+3 saptanmakla birlikte, bu oran oldukça anlamlı düzeyde yüksek bulunmuştur. LEEP ve kolposkopi işlemi yapılan olguların histopatolojik sonuçları karşılaştırıldığında kolposkopi sonucu CIN 1 olan olguların %14.5’inde, CIN 2 olan olguların %35.2’sinde LEEP sonrasında daaynı histopatolojik sonuç ile karşılaşılmıştır. Dikkat çekici olarak kolposkopi sonrası lezyon saptanmayan olguların %2.8’inde CIN 1, %2.1’inde CIN 2+3 saptanıp, 1 olguda da invaziv karsinomla karşılaşılmıştır.Sonuç: Eksizyon tedavisi için uygun hastaların belirlenmesinde smear, kolposkopi ve LEEP birbirlerini bütünleyici olarak kullanılmalıdır. Bu yöntemlerin histopatolojik sonuçlarının klinik olarak korelasyonu önemlidir.Premalign lezyonların tespit edilmesinde kolposkopi eşliğinde yapılan biyopsinin güvenilir olduğu düşünülebilir. Ancak kesin tanı ve tedavi için servikal konizasyon yöntemi halen altın standart olarak kabul edilip hastalara bu yönde bilgi verilmesi uygun bir yönetim şekli olmalıdır.Öğe Use of Stem Cell Therapy in COVID-19(2022) Özdemir, Öner; Aslan, İlke Özer; Aslan, Mustafa TörehanSevere acute respiratory syndrome coronavirus 2 is known to cause the new coronavirus disease 2019 (COVID-19), in which many organs and systems such as the lung, heart, and immune system can be severely affected. Currently, the treatment process is generally based on supportive and palliative care. Some potential drugs are being tested for treatment. At this point, perhaps a promising treatment method for many diseases in the future seems to be stem cell therapy in recent times. Stem cell therapy in COVID-19 may be a treatment method that can play an important role, especially in resistant and severe cases. In this review, we summarized the potential mechanisms of stem cell therapy and developments in this treat ment modality.
