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Öğe A Comparison of Depression and Anxiety Levels in Patients with Non-Radiographic Axial Spondyloarthropathy with Those in Patients with Ankylosing Spondylitis(Clinical & Exper Rheumatology, 2016) Barışan, E.; Solmaz, Duygu; Akar, Servet[No Abstract Available]Öğe A Comparison of Depression and Anxiety Levels in Patients with Non-Radiographic Axial Spondyloarthropathy with Those in Patients with Ankylosing Spondylitis(Bmj Publishing Group, 2016) Solmaz, Duygu; Barışan, E.; Yıldırım, Tülay; Akar, Servet[No Abstract Available]Öğe Are There Any Clues to Predict Bamboo Spine in Axial Spondyloarthritis?(Wiley, 2020) Atagündüz, Pamir; Kiraz, Sedat; Akar, Servet; Küçükşahin, Orhan; Erden, Abdulsamet; Coşkun, Nihan; Kalyoncu, Umut; Mercan, Rıdvan[No Abstract Available]Öğe Comparison of Characteristics of Ankylosing Spondylitis in Association with Familial Mediterranean Fever with Those of Typical Ankylosing Spondylitis.(Wiley-Blackwell, 2014) Solmaz, Dilek; Akar, Servet; Kısacık, Bünyamin; Apraş, Şule; Şenel, Soner; Onat, Ahmet Mesut; Akkoç, Nurullah[No Abstract Available]Öğe Different disease subtypes with distinct clinical expression in familial Mediterranean fever: results of a cluster analysis(Oxford Univ Press, 2016) Akar, Servet; Solmaz, Dilek; Kaşifoğlu, Timuçin; Yaşar Bilge, Şule; Sarı, İsmail; Gümüş, Zeynep Zehra; Tunca, MehmetObjective. The aim of this study was to evaluate whether there are clinical subgroups that may have different prognoses among FMF patients. Methods. The cumulative clinical features of a large group of FMF patients [1168 patients, 593 (50.8%) male, mean age 35.3 years (S.D. 12.4)] were studied. To analyse our data and identify groups of FMF patients with similar clinical characteristics, a two-step cluster analysis using log-likelihood distance measures was performed. For clustering the FMF patients, we evaluated the following variables: gender, current age, age at symptom onset, age at diagnosis, presence of major clinical features, variables related with therapy and family history for FMF, renal failure and carriage of M694V. Results. Three distinct groups of FMF patients were identified. Cluster 1 was characterized by a high prevalence of arthritis, pleuritis, erysipelas-like erythema (ELE) and febrile myalgia. The dosage of colchicine and the frequency of amyloidosis were lower in cluster 1. Patients in cluster 2 had an earlier age of disease onset and diagnosis. M694V carriage and amyloidosis prevalence were the highest in cluster 2. This group of patients was using the highest dose of colchicine. Patients in cluster 3 had the lowest prevalence of arthritis, ELE and febrile myalgia. The frequencies of M694V carriage and amyloidosis were lower in cluster 3 than the overall FMF patients. Non-response to colchicine was also slightly lower in cluster 3. Conclusion. Patients with FMF can be clustered into distinct patterns of clinical and genetic manifestations and these patterns may have different prognostic significance.Öğe Do major histocompatibility complex tag single nucleotide polymorphisms accurately identify HLA-B27 in the Turkish population?(Wiley, 2017) Akar, Servet; İğci, Yusuf Ziya; Sarı, İsmail; Pala, Elif; Geyik, Esra; Taş, Mehmet Nedim; Akkoç, NurullahObjectiveTo evaluate the performance of human leukocyte antigen (HLA)-B27 tag single nucleotide polymorphisms (SNPs) by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP). MethodsWe genotyped three SNPs (rs116488202, rs13202464 and rs4349859). The primers were designed using Primer3 algorithm via primer-BLAST interface. PCR products were digested by using NlaIII, BmrI and TaqI enzymes. Quality control was performed by DNA sequence analysis. ResultsIn total, 207 patients with ankylosing spondylitis and 32 healthy controls were included in the study. The sensitivity and specificity of SNPs rs116488202 and rs4349859 in identifying HLA-B27 were identical and adequate at 0.946 and 1.000, respectively. On the other hand, the sensitivity and specificity for rs13202464 was 0.878 and 0.934, respectively. The presence of another SNP (rs141774149) in close proximity to rs116488202 complicated the analysis for RFLP and required that we sequence all the T allele carrying samples. ConclusionThe SNPs rs116488202 and rs4349859 may have a place in the identification of HLA-B27 in the Turkish population; however, methods other than PCR-RFLP should be considered.Öğe Do Peripheral and Extra Musculoskeletal Manifestations Have An Impact on Biologic Dmard Prescribing Patterns in Axial Spondyloarthritis: the Results of Treasure Experience(Bmj Publishing Group, 2021) Ediboglu, E. Durak; Solmaz, Duygu; Karadağ, Ömer; Pehlivan, Yavuz; Çınar, M.; Ertenli, Ali İhsan; Akar, Servet; Mercan, Rıdvan[No Abstract Available]Öğe Evaluation of periostin and factors associated with new bone formation in ankylosing spondylitis: Periostin may be associated with the Wnt pathway(Wiley, 2018) Solmaz, Dilek; Uslu, Sadettin; Kozacı, Didem; Karaca, Neslihan; Bülbül, Hale; Tarhan, Emine Figen; Akar, ServetObjective: Periostin has been shown to be involved in bone anabolism through the regulation of Wnt-beta-catenin signaling. It may be one of the pathogenic mechanisms in syndesmophyte formation in ankylosing spondylitis (AS). The aim of this study was to evaluate serum periostin levels in patients with AS and to assess relationships among biomarkers of bone formation and periostin in disease outcomes, particularly radiographic changes. Methods: Ninety-seven consecutive AS patients (78% male) and 48 healthy controls (75% male) were included in the study. Serum periostin, dickkopf-1 (DKK-1), sclerostin and vascular endothelial growth factor (VEGF) levels were measured using commercially available enzyme-linked immunosorbent assay kits. Disease-related characteristics of patients were assessed using Ankylosing spondylitis disease activity score - C-reactive protein (ASDAS-CRP), Bath AS Disease Activity Index, Bath AS Functional Index and Bath AS metrology index. Radiographs were scored using the modified New York criteria and modified Stokes AS spinal score (mSASSS). Results: Compared with control subjects, patients with AS had significantly lower serum levels of periostin (P < 0.001) and sclerostin (P < 0.001), but higher serum levels of VEGF (P < 0.001) and high-sensitivity CRP (P < 0.001). Serum periostin (P = 0.005) and sclerostin levels (P = 0.016) were significantly lower in patients with very high disease activity according to ASDAS-CRP. Current age (P = 0.009), age at symptom onset (P = 0.021) and hip joint involvement (P = 0.012) were independently associated with the development of syndesmophyte, in contrast to biomarkers of bone metabolism that we evaluated. Conclusion: Our results suggest that periostin is down-regulated in AS patients with highly active disease and may contribute to disease pathogenesis through an interaction with Wnt signaling.Öğe Performance Characteristics of Simplified Version of Ankylosing Spondylitis Disease Activity Score (SASDAS) and Other Activity Index(Bmj Publishing Group, 2015) Solmaz, Duygu; Avcı, Okan; Tomas, Nazmiye; Akar, Servet[No Abstract Available]Öğe Performance characteristics of the simplified version of ankylosing spondylitis disease activity score (SASDAS)(Springer London Ltd, 2016) Solmaz, Dilek; Yıldırım, Tülay; Avcı, Okan; Tomas, Nazmiye; Akar, ServetVarious types of disease activity measures are available for axial spondyloarthritis (axSpA), and there is no gold standard for all individual patients. The ankylosing spondylitis disease activity score (ASDAS) is highly discriminatory, sensitive to change, and associated with structural progression. A simplified version of the ASDAS (SASDAS) was proposed and found to be a simple and practical tool to assess disease activity. Our aim was to test the performance characteristics of the SASDAS and compare it with validated tools. In total, 97 consecutive ankylosing spondylitis (AS) patients were included in the study. Disease activity was assessed by the ASDAS-erythrocyte sedimentation rate (ESR), ASDAS-C-reactive protein (CRP), bath ankylosing spondylitis disease activity index (BASDAI), and SASDAS. The relationship among these activity indices and the level of agreement of various activity categories were tested. There was a strong correlation between the SASDAS and other activity indices, including the BASDAI (r = 0.916, p < 0.001), ASDAS-CRP (r = 0.847, p < 0.001), and ASDAS-ESR (r = 0.942, p < 0.001). Although the agreement between the ASDAS-ESR and SASDAS was good (weighted kappa of 0.744 and total agreement of 77 %), there was moderate agreement between the ASDAS-CRP and SASDAS (weighted kappa of 0.579 and total agreement of 66 %). The disagreement was particularly striking in moderate and high disease activity states. Approximately 40 % of patients classified as moderate activity according to the ASDAS-ESR and 45 % according to the ASDAS-CRP were differentially categorized by the SASDAS. The results of the present analysis suggest that the simplified version of the ASDAS-ESR should be further validated in various settings and populations due to a questionable level of agreement between the ASDAS-CRP and SASDAS.Öğe Performance of different criteria sets for inflammatory back pain in patients with axial spondyloarthritis with and without radiographic sacroiliitis(Springer London, 2014) Solmaz, Dilek; Akar, Servet; Soysal, Özgül; Akkoç, Yeşim; Can, Gerçek; Gerdan, Vedat; Akkoç, NurullahIt is important to recognize inflammatory back pain (IBP) for an early diagnosis of ankylosing spondylitis (AS). Assessment of Spondyloarthritis International Society (ASAS) has recently published new criteria set for diagnosing IBP. In the present study, we evaluated the performance of the new ASAS IBP criteria and to compare the performance of IBP criteria sets in axial spondyloarthritis (axSpA) patients with and without radiographic sacroiliitis. The study sample included a total of 274 patients with a diagnosis of axSpA and 50 patients with a diagnosis of chronic (>3 months) mechanical back pain (MBP). A face-to-face interview by using a standardized questionnaire addressing all the components of IBP was performed. Data about HLA-B27 status and C-reactive protein levels were obtained from the patients’ charts. There were significantly more male patients (P < 0.001) in the AS group (68.6 %) than in the non-radiographic axSpA group (29.6 %) and also than in the MBP group (37.5 %). Among the criteria sets, the Calin criteria showed the best sensitivity (91.2 %), and the Berlin criteria showed the best specificity (82.4 %) in differentiation of IBP from MBP. If the morning stiffness item of the Calin criteria was defined as lasting >30 min (Calin 30), the specificity improved (72.9 %), but at a price of loss in sensitivity (82.4 %). In this study, new ASAS criteria for IBP performed almost as good as but not better than the existing criteria sets. Performances of the criteria sets were quite comparable in the differentiation of IBP from MBP in patients with and without radiographic sacroiliitis. © 2014, Clinical Rheumatology.Öğe Periostin May Have a Role in Ankylosing Spondylitis and It Is Associated with Wnt Signalling Pathway Regulators(Wiley-Blackwell, 2014) Akar, Servet; Uslu, Saadettin; Kozacı, Leyla Didem; Can, Gerçek; Karaca, Neslihan; Tarhan, Emine Figen; Solmaz, Dilek[No Abstract Available]Öğe Preferences of inflammatory arthritis patients for biological disease-modifying antirheumatic drugs in the first 100 days of the COVID-19 pandemic(Turkiye Klinikleri, 2021) Kalyoncu, Umut; Pehlivan, Yavuz; Akar, Servet; Kaşifoğlu, Timuçin; Kimyon, G.; Karadağ, Ö.; Kiraz, Sedat; Mercan, RıdvanBackground/aim: To evaluate treatment adherence and predictors of drug discontinuation among patients with inflammatory arthritis receiving bDMARDs within the first 100 days after the announcement of the COVID-19 pandemic. Materials and methods: A total of 1871 patients recorded in TReasure registry for whom advanced therapy was prescribed for rheumatoid arthritis (RA) or spondyloarthritis (SpA) within the 3 months (6–9 months for rituximab) before the declaration of COVID-19 pandemic were evaluated, and 1394 (74.5%) responded to the phone survey. Patients’ data regarding demographic, clinical characteristics and disease activity before the pandemic were recorded. The patients were inquired about the diagnosis of COVID-19, the rate of continuation on bDMARDs, the reasons for treatment discontinuation, if any, and the current general disease activity (visual analog scale, [VAS]). Results: A total of 1394 patients (493 RA [47.3% on anti-TNF] patients and 901 SpA [90.0% on anti-TNF] patients) were included in the study. Overall, 2.8% of the patients had symptoms suggesting COVID-19, and 2 (0.15%) patients had PCR-confirmed COVID-19. Overall, 18.1% of all patients (13.8% of the RA and 20.5% of the SpA; p = 0.003) discontinued their bDMARDs. In the SpA group, the patients who discontinued bDMARDs were younger (40 [21–73] vs. 44 years [20–79]; p = 0.005) and had higher general disease activity; however, no difference was relevant for RA patients. Conclusion: Although the COVID-19 was quite uncommon in the first 100 days of the pandemic, nearly one-fifth of the patients discontinued bDMARDs within this period. The long-term effects of the pandemic should be monitored. © TÜBİTAK.Öğe Serum Level of the Vascular Endothelial Growth Factor Is Elevated in Ankylosing Spondylitis and Osteocalcin May Be Related Wth Osteoproliferation(Bmj Publishing Group, 2015) Solmaz, Dilek; Bülbül, Hale; Uslu, Sadettin; Kozacı, Didem; Karaca, Neslihan; Akar, Servet[No Abstract Available]Öğe The Contribution of Disease Activity on Function and Quality of Life in Patients with Ankylosing Spondylitis; Investigating Causality By Using Structural Equation Model(Bmj Publishing Group, 2014) Akar, Servet; Erdem, Sabri; Akat, Kıvanç; Solmaz, Dilek; Sarı, İsmail[No Abstract Available]
