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Öğe A logarithmic model for hormone receptor-positive and breast cancer patients treated with neoadjuvant chemotherapy(Assoc Medica Brasileira, 2023) Seber, Erdoğan Selçuk; İriağaç, Yakup; Çavdar, Eyyüp; Karaboyun, Kubilay; Avcı, Okan; Yolcu, Ahmet; Gürdal, Sibel Özkan; Öznur, MeltemOBJECTIVE: The aim of this study was to investigate the predictive importance of the previously validated log(ER)*log(PgR)/Ki-67 predictive model in a larger patient population.METHODS: Patients with hormone receptor positive/HER-2 negative and clinical node positive before chemotherapy were included. Log(ER)*log(PgR)/ Ki-67 values of the patients were determined, and the ideal cutoff value was calculated using a receiver operating characteristic curve analysis. It was analyzed with a logistic regression model along with other clinical and pathological characteristics.RESULTS: A total of 181 patients were included in the study. The ideal cutoff value for pathological response was 0.12 (area under the curve=0.585, p=0.032). In the univariate analysis, no statistical correlation was observed between luminal subtype (p=0.294), histological type (p=0.238), clinical t-stage (p=0.927), progesterone receptor level (p=0.261), Ki-67 cutoff value (p=0.425), and pathological complete response. There was a positive relationship between numerical increase in age and residual disease. As the grade of the patients increased, the probability of residual disease decreased. Patients with log(ER)*log(PgR)/Ki-67 above 0.12 had an approximately threefold increased risk of residual disease when compared to patients with 0.12 and below (odds ratio: 3.17, 95% confidence interval: 1.48-6.75, p=0.003). When age, grade, and logarithmic formula were assessed together, the logarithmic formula maintained its statistical significance (odds ratio: 2.47, 95% confidence interval: 1.07-5.69, p=0.034).CONCLUSION: In hormone receptor-positive breast cancer patients receiving neoadjuvant chemotherapy, the logarithmic model has been shown in a larger patient population to be an inexpensive, easy, and rapidly applicable predictive marker that can be used to predict response.Öğe A Rare Case in Urology: Inflammatory Myofibroblastic Tumour(Coll Physicians & Surgeons Pakistan, 2022) Akgül, Murat; Şahin, Mehmet Fatih; Arslan, Ayşegül; Öznur, Meltem; Yazıcı, CenkInflammatory myofibroblastic tumour (IMT) is a soft tissue malignancy with a mixture of myofibroblastic spindle cells with hyalinised stroma and inflammatory infiltrates. We report a case of a 35-year male patient with a 100x90 mm mass located at the posterior wall of the urinary bladder just adjacent to the prostate and rectum. The mass caused grade 3 hydronephrosis in the left kidney and grade 1 hydronephrosis in the right kidney. The patient was operated and the mass lesion was excised completely. Because the left ureter was adherent to the mass, it was excised at the most distal part and uretero-neo-cystostomy was performed as the bladder and the prostate were preserved. Morphology and immunohistochemistry were consistent with IMT. With surgical excision of the tumour, no recurrence or metastases were seen up to 3 years postoperatively.Öğe A rare cause of virilization; Ovarian steroid cell tumor, not otherwise specified (NOS)(Galenos Yayincilik, 2012) Taşdemir, Nicel; Çelik, Cem; Abalı, Remzi; Aksu, Erson; Öznur, Meltem; Yılmaz, MuratSex cord-stromal tumors account for 5% of ovarian tumors and 2% of malignant ovarian tumors. Steroid cell tumors (SCT), not otherwise specified (NOS), are rare sex cord-stromal tumors of the ovary and account for less than 0.1% of all ovarian tumors. We report a rare case of a postmenopausal woman presented with hirsutism, virilism and with findings of hyperestrogenism.Öğe A synchronous occurrence of urothelial carcinoma with abundant myxoid stroma and inverted papilloma of the urinary bladder(Pagepress Publ, 2012) Behzatoğlu, Kemal; Yıldız, Pelin; Öznur, Meltem; Bozkurt, Erol RüştüAbundant myxoid stroma rarely occurs in urothelial carcinomas, and may cause diagnostic challenges when cells with eosinophilic cytoplasm forming nests and cords in a myxoid background are seen, particularly in the absence of typical carcinomatous appearance. Microscopic examination of transurethral resection specimen of a 71-year-old male patient revealed non-cohesive oval or elongated tumor cells with eosinophilic cytoplasm arranged in cord-like filigree pattern in an abundant myxoid stroma. Immunohisto chemically the tumor was positive for cytokeratin 7, cytokeratin 20, and 34BE12. About 90 to 100% nuclear staining was observed with p63, p53, and Ki-67. A second neoplasm with a flat overlying urothelial epithelium and a complete inverted cellular growth pattern was also noted. The neoplasm exhibited less than 2% and 10% nuclear staining with Ki-67 and p53, respectively. Considering histological, histochemical, and immunohistochemical findings, a diagnosis of synchronous urothelial carcinoma with abundant myxoid stroma and inverted papilloma was made.Öğe Acute Kidney Injury in a Case of Purpura Fulminans Developing Secondary to Antithrombin 3 Deficiency(Medical Assoc Nippon Medical Sch, 2018) Özkan, Gülsüm; Emeksiz, Gaye Kübra; Atar, Reşit Volkan; Sedef, Samet; Kara, Sonat Pınar; Öznur, Meltem; Turgut, BurhanPurpura fulminans associated with antithrombin 3 (AT 3) deficiency is very rare in adults and neonates. It can be categorized into three principal forms - neonatal, idiopathic and acute infectious. Purpura fulminans has been reported to cause cardiac, pulmonary and renal damage in rare cases We describe an adult case of purpura fulminans developing in association with AT 3 deficiency without infection following a surgical procedure, and acute kidney injury (AKI) developing secondary to rhabdomyolysis and disseminated intravascular coagulation (DIC). To the best of our knowledge there have been no previous cases of purpura fulminans and AKI developing in association with acquired AT 3 deficiency without infection after surgery.Öğe Analysis of Cervical Cytology, Colposcopy and Biopsy Results(Derman Medical Publ, 2015) Taşdemir, Nicel; Çelik, Cem; Abalı, Remzi; Öznur, Meltem; Akbaba, ErenAim: Cervical cancer incidence and mortality have been significantly reduced by the regular and population based application of cervical cancer screening programme. Five percent of patients in screening programme need to be treated with further diagnostic tools. The most commonly used technique for further evaluation is colposcopy. In this study we evaluated the results of colposcopy procedure, which had been carried out in our clinical setting, together with the cytology and tissue biopsy results. Material and Method: One hundred ninety colposcopy procedures, which had been carried out in gynecology clinic of Namik Kemal University Faculty of Medicine, Department of Obstetrics and Gynecology, were evaluated retrospectively. Colposcopy indications and results, cytology results and biopsy results were evaluated. Results: The mean age of the population was 42.8 +/- 10.4. Forty-four (23.2%) of patients were postmenopausal and 146 (76.8%) were premenopausal. The 51 (26.8%) patients were smoking. Colposcopy indication for 42 (22.1%) patients was visible lesions on the cervix. Colposcopy indication for the rest of the population was abnormal cervical smear results. Colposcopy was negative for the 49 (25.8%) patients. The biopsies revealed no dysplasia for 153 (80.5%) patients, CIN 1 for 17 (8.9%) patients, CIN 2 for 9 (4.7%) patients, CIN 3 for 7 (3.7%) patients, in situ squamous carcinoma for 2 (1.1%) patients, squamous carcinoma for 2 (1.1%) patients. Random biopsies from colposcopy negative patients revealed CIN 3 for 1 patient and CIN 2 for 2 patients. These 3 patients represented 6.1% of colposcopy negative patients. The sensitivity of colposcopy for detecting CIN 2 and higher-grade lesions were 85 % in our study. Discussion: The main goal of the cervical screening programme is to detect CIN 3 lesions. Our results supports recent findings in literature suggesting random cervical biopsies in colposcopy negative patients, especially in patients who have risk for high-grade dysplasia in their cervical smear such as HSIL or ASC-H, should be done to improve sensitivity of colposcopy.Öğe Ascaris lumbricoides presenting as an omental mass(Carbone Editore, 2014) Özyalvaçlı, Gülzade; Küçükbayrak, Abdülkadir; Uzuner, Esengül; Ayar, Erol; Öznur, MeltemIntroduction: Ascaris lumbricoides (AL), is an intestinal Parasite with various clinical presentations. It is common in underdeveloped rural areas both in Turkey and in the rest of the World; Ectopic localizations of AL are rare, and there only a few reported cases of mental localization. Case: We present a rare case in which an omental and a paratubal mass were detected during cesarean section in an asymptomatic pregnant patient. The histopathological examination revealed a granulomatous reaction and AL eggs inside the masses. Discussion: Infection With AL causes various intestinal complications like acute appendicitis, volvulus, invagination, intestinal perforation and gramdotnatous peritonitis. Conclusion: It should be kept in mind that granulomatous lesions presenting as mental masses may be randomly detected in asymptomatic individuals and pregnant woman infected with AL.Öğe Comparison of colorectal neoplastic polyps and adenocarcinoma with regard to NLR and PLR(Verduci Publisher, 2015) Emir, Seyfi; Aydın, M.; Can, G.; Bali, İlhan; Yıldırım, Oğuzhan; Öznur, Meltem; Gürel, A.OBJECTIVE: Cancer-related inflammation affects many aspects of malignancy, including proliferation and survival of malignant cells, angiogenesis, and therapeutic response. Some biomarkers representing the degree of systemic inflammation, such as the Glasgow prognostic score, NLR and PLR, have been shown to have prognostic value in many kinds of cancer patients. Aim of this study to investigate to compare neutrophil/leukocyte (NLR) and platelet/lymphocyte (PLR) ratios of the patients with colorectal neoplastic polyps and colorectal cancer (CRC) and tried to determine whether this could be used as a biomarker in follow up of the patients with neoplastic polyps. PATIENTS AND METHODS: A total of 100 colorectal polyps, 113 colorectal cancers and 124 healthy controls were included in the study. Exculusion criteria were endocrinologic or metabolic diseases, acute or chronic diseases, hypertension and atherosclerotic heart diseases, renal diseases. Blood count parameters of the patients were measured. The NLR was calculated as a simple ratio between the absolute neutrophil and the absolute lymphocyte counts. The PLR was defined as the platelet counts to lymphocyte ratio. RESULTS: A statistically significant difference was not detected between Group A and C with regard to NLR and PLR. NLR and PLR were found statistically significantly high in Group B (CRC), Group A (colorectal polyp) and Group C (healthy individuals) (p < 0.001 and p < 0.001). Our study showed that the optimum NLR cutoff point for neoplastic polyps was 2.28 (sensitivity: 68.7%, specificity: 42.3%). When the sensitivity and specificity levels of the PLR were assessed, they were 68.7% and 46.5% for neoplastic polyps, 80% and 68.9% for colorectal cancer. CONCLUSIONS: NLR and PLR may be used for follow up conversion of colonic and rectal neoplastic polyps to invasive tumor.Öğe Cytological features of pure micropapillary carcinoma of various organs: A report of eight cases(Spandidos Publ Ltd, 2014) Huq, Gülben Erdem; Canberk, Sule; Öznur, Meltem; Yıldız, Pelin; Bahadir, Burak; Behzatoğlu, KemalMicropapillary carcinoma (MPC) is a rare aggressive tumor, which generally accompanies the primary carcinoma of the organ of its origin, while the pure form is extremely uncommon. Angiolymphatic involvement is widespread and a considerable proportion of the cases present with metastases. The current study presents eight pure MPC cases arising from the breast (n=3), urinary bladder (n=3), parotid gland (n=1) and lung (n=1, presenting with pericardial effusion), with the cytological findings. The eight patients included three female and five male cases aged between 48 and 74 years. The most common cytological findings were three-dimensional aggregates, cell clusters with angulated or scalloped borders, single cells with a columnar configuration and eccentric nuclei, and high-grade nuclear features. Histopathological sections showed accompanying in situ ductal carcinoma in the cases of MPC arising in the parotid gland and breast (n=3), and one case in the bladder exhibited only in situ MPC. The average follow-up period was 20 months (range, 6-54 months) and, during this period, three patients succumbed to the disease. At present, four patients are alive with disease and one patient is alive and disease-free. In conclusion, cytology is an important tool for the diagnosis and management of MPC.Öğe Digital Mammography, Ultrasound and Magnetic Resonance Imaging Characteristics in Differential Diagnosis of Papillary Carcinoma Subtypes of the Breast and Diagnostic Challenges(Galenos Yayincilik, 2022) Kurtoğlu Özçağlayan, Tuğba İlkem; Öznur, MeltemObjective: We aimed to investigate mammography (MG), ultrasound (US), and magnetic resonance imaging (MRI) findings of papillary breast carcinoma subtypes and to compare the diagnostic features and performance of the imaging method in distinguishing subtypes. Materials and Methods: Forty-two patients presenting with pathological diagnosis of 45 papillary carcinoma lesions, between 2014 and 2019, were included. Cases were assigned to five subgroups according to the latest World Health Organization (WHO) classification. The clinical characteristics (n = 45) and imaging features of each pathological subgroup were retrospectively related to imaging findings from US (n = 45), MG (n = 37), and breast MRI (n = 23), and further compared. Results: The finding of a palpable mass in all subgroups was more common than nipple discharge on clinical breast evaluation, and no significant difference was found between the subgroups. Irregular shape on MG (10/12, 83.3%, p = 0.039) and US (11/12, 91.7%, p = 0.039) was found more frequently in invasive micropapillary carcinoma (IMPC) compared to other subgroups. Circumscribed margins (4/5, 80%, p = 0.002) occurred more frequently in papillary ductal carcinoma in situ (pDCIS) and encapsulated papillary carcinoma (EPC) than in other subgroups (6/8, 75%, p = 0.002). Lower apparent diffusion coefficient (ADC) values were found in solid papillary cancer (SPC) than in other subgroups (ADC = 0.35 x 10(-3), p = 0.017). Conclusion: Radiological findings of papillary carcinomas overlap with each other. US and MRI are complementary when revealing specific morphological characteristics.Öğe Effectiveness of the diagnostic pathway of BLES: could it be safely used as a therapeutic method in selected benign Lesions?(Turkish Soc Radiology, 2019) Kurtoğlu Özçağlayan, Tuğba İlkem; Gürdal, Sibel Özkan; Öznur, Meltem; Özçağlayan, Ömer; Doğru, Mücahit; Topçu, BirolPURPOSE In this study, we aimed to investigate the breast lesion excision system (BLES) as a tool and a practical alternative technique to surgical biopsy and other percutaneous biopsy methods for spicious lesions. We also wanted to share our initial experience with BLES and compare it with standard percutaneous biopsy methods. METHODS From July 2015 to December 2016, a total of 50 patients who had high-risk lesions which were diagnosed with core needle biopsy (CNB) or had lesions with radiology pathology discordance, or had high-risk factors, high-grade anxiety, or suspicious follow-up lesions were enrolled in the study.These lesions were classified as Breast Imaging Reporting and Data System (BI-BADS) 3 or 4, which are under 2 cm. Pathologic diagnoses before and after BLES were evaluated comparatively. The diagnostic and therapeutic success and the complications of CNB and BLES were analyzed. RESULTS After BLES, two cases were diagnosed as atypical lobular hyperplasia and atypical ductal hyperplasia. Since the surgical margin was negative, re-excision was not required. Two cases were diagnosed as malignant, and no residual tissue was detected in the operation region. Total excision rates were reported as 56%. Minor hematoma was observed in only 1 out of 50 cases (2%), and spontaneous remission was observed. Two patients (4%) complained of pain during the procedure. Radiofrequency-related thermal damage to the specimen showed: Grade 0 (<0.5 mm) damage in 88%, Grade 1 (0.5-1.5 mm) in 10%, Grade 2 (>1.5 mm or thermal damage in diffuse areas) in 2%, and Grade 3 (diffuse thermal damage or inability to diagnose) in 0%. We found a significant positive correlation between classification of thermal damage and lesion fat cell content (r = 0.345, P = 0.015). CONCLUSION BLES is a safe technique that can be effectively used with low complication rates in the excision of benign and high-risk breast lesions in selected cases. It may also provide high diagnostic success and even serve as a therapeutic method in high-risk lesions, such as radial scar, papilloma, and atypical lobular hyperplasia with high complete excision rates without fragmentation of lesions.Öğe For which non-muscle invasive bladder cancer is Re-Transurethral Resection more valuable? Which bladder cancer deserves Re-TUR?(Bayrakol Medical Publisher, 2021) Akgül, Murat; Doğan, Çağrı; Yazıcı, Cenk Murat; Şahin, Mehmet Fatih; İşal Arslan, Ayşegül; Öznur, MeltemAim: In this study, we aimed to evaluate the re-transurethral resection (re-TUR) pathologies and to compare the pathology results between transurethral resection of the bladder (TUR-B) and re-TUR for non-muscle invasive bladder cancer (NMIBC). Additionally, we aimed to assess the factors affecting the re-TUR pathology and try to define more valuable re-TUR patient groups. We also aimed to evaluate the effect of re-TUR on recurrence and progression. Material and Method: We performed re-TUR in intermediate/high-risk NMIBC patients, 4-6 weeks after the index TUR-B. Both TUR-B and re-TUR pathology characteristics, including tumor stage, grade, size, number, lymphovascular invasion (LVI), carcinoma in situ (CIS), variant pathology, and intermediate/high-risk status were analyzed retrospectively. The recurrence and progression rates were also evaluated according to re-TUR. Results: A total of 78 patients with NMIBC were included in the study. The index TUR-B pathologies were Ta-Low: 6 (7,7%), Ta-High: 5 (6,4%), T1-Low: 14 (17,9%), T1-High: 53 (67,9%). Re-TUR positivity was n: 40 (51 %), and upstaging/upgrading at re-TUR was n: 11 (14 %) in all groups. Re-TUR positivity was significantly higher in high-risk compared to intermediate-risk NMIBC (p:0,026). Re-TUR positivity was higher in patients with hydronephrosis, C15. LVI, differentiation, size (>3 cm), and multiple tumor presence (p<0,05). There was no significant relationship between recurrence/progression and re-TUR (p>0,05). Discussion: Residual tumor was common after the index TUR-B, and upstaging after re-TUR was very important Re-TUR is critically important in high-risk NMIBC, presence of hydronephrosis, CIS, LVI, variant pathology, size (>3 cm). and multiple number of tumors.Öğe Gastric gastrointestinal stromal tumor with bone metastases - Case report and review of the literature(Czech Medical Association J.E. Purkyne, 2014) Şahin, E.; Yetişyiğit, Tarkan; Öznur, Meltem; Elboğa, UmutGastrointestinal stromal tumors (GISTs) represent rather rare neoplasms. Most GISTs are benign; malignant tumors account for 20-30% of cases (overall, approximately 10-30% of GISTs exhibit malignant behavior). GISTs most commonly metastasize to the liver and abdominal cavity. Distant metastases to other sites, especially to the bones, are relatively rare. We report a case of a 62-year-old man with metastatic spread of GIST to skull, ribs and both sacroiliac joints manifesting six months after surgical resection of a gastric tumor. Although bone metastases from GISTs are rare and there are only a few reported cases in the literature, this case emphasizes that metastatic disease should always be considered in a patient with gastric GIST and suspicious bone lesions.Öğe Human Papilloma Virüs (HPV) Varlığının Cinsel Aktif Kadınlarda Moleküler Metodlarla Değerlendirilmesi(2019) Yöntem, Mustafa; Gümüş, Abdullah; Abalı, Remzi; Öznur, Meltem; Erci, Fatih; Erdoğdu, Behiç SelmanBu çalışmada, anormal smear tanısı konan hastalarda, smear ve biyopsi materyallerinde PCR yöntemi ile HPV DNA analizi yapılarak sonuçların biyopsi tanısıyla karşılaştırılması amaçlanmıştır. Çalışma, yaşları 26 ile 74 arasında değişen 24 hasta üzerinde gerçekleştirilmiştir. Ele alınan vakalardan patolojik değerlendirme sonucunda H-SIL, L-SIL veya ASCUS ile anormal smear tanısı konmuş hastalara kolposkopik biyopsi yapılarak örnekler elde edilmiş ve moleküler testler ile HPV varlığı araştırılmıştır. Kolposkopi öncesinde hastalara anket uygulanarak demografik bilgiler elde edilmiş ve HPV enfeksiyonuna neden olabilecek faktörlerin varlığı incelenmiştir. Anormal smear sonucuna sahip hastalardan alınan patolojik örneklerde, biyopsi tanısı %33’ünde serviks CA, %4’ünde H-SIL, %13’ünde L-SIL ve %50’si normal olarak bulunmuştur. Ayrıca, normal smear sonucuna sahip tüm hastaların %33’ünde HPV DNA belirlenmiş ve belirlenen HPV alt tipleri (HPV 16, HPV 18, HPV 31 ve HPV 58) arasında en yüksek oranda izlenen alt tipin HPV 16 olduğu tespit edilmiştir. HPV 16 bulunan 5 hastadan 4’ünün biyopsi tanısının serviks CA olduğu tespit edilmiş, kalan 1 hastanın ise H-SIL olduğu görülmüştür. Ayrıca, partner sayısı 1’den fazla olan kişilerde HPV pozitiflik oranının yüksek olduğu görülürken, HPV pozitif vakaların tamamının gravide sayısının üç veya üzeri olduğu gözlenmiştir. Bu çalışmada patolojik tanı yöntemleri ve mikrobiyolojik inceleme sonuçlarının tanıya katkısı ortaya konulmuş, tarama programlarının ve erken teşhisin önemi bir kez daha ortaya çıkarılmıştır.Öğe İğsi hücreli lipomun histolojik özellikleri ve ayırıcı tanı problemleri(2012) Öznur, Meltem; Canberk, Şule; Yıldız, Pelin; Özyalvaçlı, Gülzade; Baykal, Sevim; Erdem Huq, Gülben; Bozkurt, Erol RüştüAMAÇ: İğsi hücreli lipomun histolojik ve tipik immunhistokimyasal özelliklerini araştırmak ve diğer subkutan yerleşimli benzer histolojik ve immunhistokimyasal özellikleri olan neoplazmlarla ayırıcı tanısını yapmaktır. YÖNTEMLER: İstanbul Eğitim ve Araştırma Hastanesi patoloji laboratuarında lipom tanısı almış 3100 olguda son Dünya Sağlık Örgütü Yumuşak Doku Tümörleri Sınıflamasına göre alt tipler belirlendi ve bunların içinden 22 İHL çalışmaya alındı. 22 iğsi hücreli lipom olgusunda klinik (yaş, lokalizasyon, cinsiyet, nüks), morfolojik özellikler (tümör boyutu, alt tip, histoloji, mast hücre varlığı ve immunhistokimya), tümörlerin natürü ve ayrıcı tanı problemleri değerlendirildi. BULGULAR: 3100 lipomun alt tiplere göre dağılımı şu şekildeydi: 2864 klasik lipom (%90), 293 anjiyolipom (%9), 1 kondroid lipom (%0.03), 1 miyolipom (%0.03 ve 22 iğsi hücreli lipom (% 0.7). 22 iğsi hücreli lipomların 9’u fibröz, 3’ü miksoid, 1’i anjiyomatoid ve 9’u nonfibröz alt tipti. Erkek kadın oranı 18/4 olarak belirlendi. Olguların 2’si sırt, 3’ü omuz, 1’i ön kol, 1’i oral olup 15’ü baş-boyun bölgesinde lokalize idi. Ortalama tümör çapı 3.2 cm olup en büyük ve küçük çaplar 1 cm ve 6.1 cm olarak ölçüldü. Fibromatöz alt tipte belirgin olmak üzere Toluidin blue boyasıyla her olguda mast hücresi mevcuttu. Mast hücre sayısı on büyük büyütme alanında ortalama 23 olarak bulundu. S–100 tüm iğsi hücrelerde negatif ve yağ hücrelerinde pozitif olarak tespit edildi. CD34 olguların 21’inde pozitif, 1’inde negatif bulundu. Hiçbir olguda nüks izlenmedi. SONUÇ: İğsi hücreli lipom, subkutan lokalizasyonlu, iyi sınırlı, iğsi hücreli komponenti CD34 pozitif, mast hücrelerinden zengin bir tümör olup birçok subkutan tümörle ayırıcı tanı yapılmasını gerektiren nadir bir antitedir.Öğe In vitro culture of tumor infiltrating lymphocytes for adoptive immunotherapy in breast cancer patients(Elsevier Sci Ltd, 2018) Şeber, Erdoğan Selçuk; Yetişyiğit, Tarkan; Turgut, Burhan; Buluş, Stephen; Gürdal, Sibel Özkan; Öznur, Meltem[No Abstract Available]Öğe Inverted (hobnail) high-grade prostatic intraepithelial neoplasia and invasive inverted pattern(Spandidos Publ Ltd, 2015) Öznur, Meltem; Baykal Koca, Sevim; Yıldız, Pelin; Bahadır, Burak; Behzatoğlu, KemalHigh-grade prostatic intraepithelial neoplasia (HGPIN) is considered to be an important precursor for prostatic adenocarcinoma. The present study aimed to investigate the histological features of the uncommon inverted (hobnail) pattern of HGPIN in transrectal ultrasonographic (TRUS) prostatic needle biopsies from 13 cases. These 13 diagnosed cases of inverted HGPIN were identified out of a total of 2,034 TRUS biopsies (0.63%), obtained from patients suspected to have prostate cancer. The hobnail pattern is comprised of secretory cell nuclei, which are histologically localized at the luminal surface of the prostate gland, rather than the periphery, and exhibit reverse polarity. Histological examinations were performed and the results demonstrated that 5 of the 13 cases exhibited pure inverted histology, while HGPIN was observed to be histologically associated with other patterns in the remaining 8 patients. In addition, an association with adenocarcinoma was identified in 7 of the 13 cases. All 7 carcinomas accompanied by inverted HGPIN were conventional acinar adenocarcinoma cases; of note, for these 7 cases, the Gleason score was 7 for each. One acinar adenocarcinoma case accompanying inverted HGPIN demonstrated hobnail characteristics in large areas of the invasive component. It was observed that nuclei were proliferated in the invasive cribriform glands, which was comparable to that of inverted HGPIN, and were located on the cytoplasmic luminal surface; a similar morphology was also observed in individual glands. In conclusion, the results of the present study suggested that the hobnail HGPIN pattern may be of diagnostic importance due to its high association with adenocarcinoma and the high Gleason scores in the accompanying carcinomas.Öğe Investigation of the Effect of Low-positive HER-2 on Neoadjuvant Chemotherapy Response in Hormone-positive Breast Cancer Patients(2023) Karaboyun, Kubilay; Öznur, Meltem; Yolcu, Ahmet; İriağaç, Yakup; Şeber, Erdoğan SelçukObjective: Recently, it has been suggested that low-positive human epidermal growth factor receptor-2 (HER-2) is a separate group of breast cancer. We examined the effect of low-positive HER-2 on neoadjuvant chemotherapy (NACT). Methods: This retrospective study included female patients aged >18 years who were diagnosed with histologically proven breast cancer between January 1, 2016, and January 1, 2020, and had breast surgery after NACT. Patients with triple-negative, estrogen receptor (<10%) weak positive, HER-2 immunohistochemical (IHC) scores 3+ or 2+/FISH-positive patients, and metastatic patients were excluded. Pathological complete response (pCR) was defined as the no invasive and in situ residue in the breast and lymph nodes in surgery after NACT. Results: One hundred twenty seven patients were included in this study. HER-2 IHC-score “0” patients were 55 (43.3%), “1+” patients were 52 (40.9%), and “2+” patients were 20 (15.7%). Nine (7.1%) patients showed a complete response to NACT. In the univariate analysis with clinicopathological variables of the patients to predict the complete response to NACT; estrogen receptor [odds ratio (OR): 0.97, 95% confidence interval (CI): 0.96-0.99, p=0.012], Ki-67 (OR: 1.12, 95% CI: 1.06-1.18, p<0.001), tumor grade (OR: 0.036, 95% CI: 1.13-30.36, p=0.036), and lymphovascular invasion (OR: 0.11, 95% CI: 0.01-0.93, p=0.043) showed the predictive features. In the multivariate analysis, Ki-67 (OR: 1.10, 95% CI: 0.04-1.17, p=0.001) was found to be an independent predictor of pCR. Conclusion: We determined that the low-positive-HER2 group has no effect on the treatment response in patients treated with NACT. We found that Ki-67 was an independent predictive for pCR.Öğe Leukocytoclastic vasculitis due to duloxetine(John Libbey Eurotext Ltd, 2015) Erfan, Gamze; Alp, Recep; Albayrak, Şule; Oğuz, Keriman; Kalayci, Serkan; Öznur, Meltem; Kulaç, Mustafa[No Abstract Available]Öğe Lichen nitidus presenting with trachyonychia(Medknow Publications & Media Pvt Ltd, 2017) Albayrak, Hülya; Yanık, Mehmet Emin; Erfan, Gamze; Öznur, Meltem; Kulaç, Mustafa[No Abstract Available]
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