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Öğe Biochemical polymorphism of erythrocyte potassium and glutathione protein: the relationship with some blood parameters in Kivircik sheep breed(Academic Journals, 2010) Gürcan, Eser Kemal; Erbas, Cengizhan; Çobanoglu, ÖzdenThis paper aims to search genetic structures of purebred Kivircik sheep raised in Turkey based on erythrocyte potassium and glutathione types and also to determine the relationship between these components and some blood parameters. The phenotypic frequencies were 68% for LK and 32% for HK erythrocyte potassium types in the purebred Kivircik breed. The allele gene frequency of K H and K L loci were calculated as 0.56 and 0.44 respectively. There was no relationship detected between gender factor and blood parameters. But, significant relationships were obtained between erythrocyte potassium types and some blood parameters (Na-wb, Na-e, K-wb, K-p, K-e, Na-e + K-e; p<0, 05). At the same time, the correlation coefficient between Ke and Nae was calculated as R = -0.58, (p<0.01). But, correlation coefficient was not significant between blood parameters and hematocrit value (PCV). All animals were detected as low types in terms of glutathione level (GSH(h)). The mean of erythrocyte glutathione was determined as 29.79 mg/dL in red blood cell. The mean of erythrocyte potassium concentrations (Ke) were 9.22 and 23.47 mmol/L for the LK and HK types of animals, respectively and the mean differences between LK and HK types were statistically important in this study (p<0.01).Öğe Detennination of erythrocyte potassium and glutathione polymorphism in Saanen, Maltese and Turkish hair goats(2011) Çobanoglu, Özden; Gürcan, Eser Kemal; Pala, A.Main purpose of this study was to investigate genetic polymorphisms of Saanen (S), Maltese (M) and Turkish Hair (TH) goats based on erythrocyte potassium and glutathione types. It was also designed to detect the association between these components and some blood parameters depending on the breed comparisons. The phenotypic and alleles frequencies were calculated for potassium and glutathione types of all three breeds. The difference between low and high potassium (LK and HK, respectively) types for the means of erythrocyte potassium concentration (Ke) were statistically important for all breeds (p<O.Ol). The significant relationships between erythrocyte potassium types and blood parameters of erythrocyte sodium (Nae), whole blood potassium (Kwb), plasma potassium (Kp), erythrocyte potassium (Ke) were observed for S and TH goats. On the other hand, the important relationships were detected between erythrocyte potassium types and blood parameters of whole blood sodium (Nawb), Nae, KwbKp Ke, total monovalent cation concentration in erythrocyte (Nae+Ke) for M goat breed (p<0.05). The correlation coefficient between Na, and K, blood parameters was important and it was ranged from -0.26 to -0.34. In addition, Maltese goat breeds had a higher K, than the others but Na, was higher in TH goats. Even if parity and birth type differences were not statistically important for all blood parameters, there was indication of significant differences for these values except hematocrit value (peV), N~ and GSH concentrations depending on the potassium types within breed (p<0.05) and also among all breed analyses (p<O.OOI). © Medwell Journals, 2011.Öğe Determination of Body Weight-Age Relationship by Non-Linear Models in Japanese Quail(Medwell Online, 2012) Gürcan, Eser Kemal; Çobanoglu, Özden; Genç, SerdarThe objectives of this study were to determine the body weight-age with different models and to choose the best fitted model. The study was designed to collect a total of 8 weekly body weight records from 142 quails from birth up to 56 days of age in Tekirdag, Turkey, The Negative Exponential, Brody, Gompertz, Logistic and Bertalanffy Models were used to determine growth characteristics of quail in the present study. The model parameters were calculated for each model and the comparisons among the models were done based on the coefficient of determination (R(2)), adjusted coefficient of determination (R(adj)(2)), Mean Square Error (MSE), the Akaike's Information Criteria (AIC), Residual Standard Deviation (RSD) and Residual Mean (RIVI) as fit criteria. As a conclusion, the Logistic Model (R(2) = 0.98, R(2) = 0.97, MSE = 9.79, AIC = 20.49, RSD = 3.13 and RM = 6.42) resulted in the best fit model for body weight-age in Japanese quail.Öğe Determination of Erythrocyte Potassium and Glutathione Polymorphism in Saanen, Maltese and Turkish Hair Goats(Medwell Online, 2011) Çobanoglu, Özden; Gürcan, Eser Kemal; Pala, AkinMain purpose of this study was to investigate genetic polymorphisms of Saanen (S), Maltese (M) and Turkish Hair (TH) goats based on erythrocyte potassium and glutathione types. It was also designed to detect the association between these components and some blood parameters depending on the breed comparisons. The phenotypic and alleles frequencies were calculated for potassium and glutathione types of all three breeds. The difference between low and high potassium (LK and HK, respectively) types for the means of erythrocyte potassium concentration (K-e) were statistically important for all breeds (p<0.01). The significant relationships between erythrocyte potassium types and blood parameters of erythrocyte sodium (Na-e), whole blood potassium (K-wb), plasma potassium (K-p), erythrocyte potassium (K-e) were observed for S and TH goats. On the other hand, the important relationships were detected between erythrocyte potassium types and blood parameters of whole blood sodium (Na-wb), Na-e K-wb, K-p, K-e, total monovalent cation concentration in erythrocyte (Na-e+K-e) for M goat breed (p<0.05). The correlation coefficient between Na-e and K-e blood parameters was important and it was ranged from -0.26 to -0.34. In addition, Maltese goat breeds had a higher K-e than the others but Na-e was higher in TH goats. Even if parity and birth type differences were not statistically important for all blood parameters, there was indication of significant differences for these values except hematocrit value (PCV), Na-p and GSH concentrations depending on the potassium types within breed (p<0.05) and also among all breed analyses (p<0.001).Öğe Determination of the association of GHR/Alul gene polymorphisms with milk yield traits in Holstein and Jersey cattle raised in Turkey(Copernicus Gesellschaft Mbh, 2021) Çobanoglu, Özden; Kul, Ertuğrul; Gürcan, Eser Kemal; Abaci, Samet Hasan; Çankaya, SonerThis research was carried out to determine the effect of a specific single nucleotide polymorphism (SNP) region in exon 10 of the growth hormone receptor (GHR) gene on milk production traits in Jersey and Holstein cows raised in Turkey. Milk samples were recorded as a test day milk yield (TDMY) and an adjusted based 305 d milk yield (305-DMY). Also, milk component traits were detected. Based on the scope of this study, a total of 748 dairy cows, including 305 Holsteins raised in the Marmara Region and 163 Holstein and 280 Jersey raised in the Black Sea Region, were genotyped for the GHR gene using the RFLP-PCR technique. Jersey cows carrying the GG genotype (5.24 %) were associated with higher fat content (P < 0.05). Jersey cows with GG and AG also had a higher protein content (3.44 % and 3.38 %, respectively) (P < 0.05). Similarly, the protein content was the highest in Holstein cows with the GG genotype (3.46 %) (P < 0.01), whereas Holstein cows having AA genotypes displayed higher TDMY (24.64 kg/d) (P < 0.05) and 305-DMY (8472.4 kg) (P < 0.01). The estimated increase in milk protein and fat contents due to the G allele was 0.07 % and 0.22 % in the Jersey breed, respectively. On the other hand, allele A was highly related to an increase in protein yield and 305-DMY of 0.04 and about 675 kg in the Holstein breed, respectively. The GHR gene should be considered as a potential candidate gene in marker-assisted selection programs to improve the performance of milk and related traits in Turkey dairy cattle populations.Öğe Determination of the genetic polymorphism for DGAT1 gene in Holstein, Jersey and native cattle breeds of Turkey(Agricultural Research Communication Centre, 2019) Gürcan, Eser Kemal; Çobanoglu, Özden; Kul, Ertuğrul; Abacı, Samet Hasan; Çankaya, SonerThis study was to determine the genetic polymorphism in terms of the DGAT1 gene among Holstein and Jersey and indigenous Native Black, East Anatolian Red and Grey Steppe in Turkey. The frequencies of K allele for the DGAT1 gene were calculated as 0.59, 0.54, 0.53, 0.62, 0.52, and 0.54 for Jersey, Holstein (Black Sea Region), Holstein (Marmara Region), and Grey Steppe, East Anatolian Red, and Native Black breeds, respectively. The F-IS values of the populations for the DGAT1 gene were detected all negative values. In overall population, F-IS value was found as 76%. The expected deviations from the Hardy-Weinberg Equilibrium in terms of the DGAT1 locus were found significant in these six different populations (P<0.01). The genetic distance values among the populations were calculated between 0.0001 and 0.0089. Based on the cluster analysis, Holstein, Native Black and East Anatolian Red were located in close cluster; however, Jersey and Grey Steppe were grouped in different cluster.Öğe Effects of lactation month and season on test-day milk yield and milk components in Holstein cows(Agricultural Research Communication Centre, 2017) Çobanoglu, Özden; Gürcan, Eser Kemal; Çankaya, Soner; Kul, Ertuğrul; Abaci, Samet Hasan; Ülker, MehmetThis study aims to determine the correlations between the test-day milk yield (TDMY) and the fat and protein content as well as the fat and protein yields in Holstein dairy cows and to investigate the effects of lactation period and sampling season on these parameters. The study material consists of 1.380 records of a total of 151 head of Holstein dairy cows raised on a private farm in Samsun province. In the study, the mean TDMY, fat content, protein content, fat yield and protein yield were recorded as 20.6 +/- 5.10 kg, 3.97 +/- 0.734%, 3.23 +/- 0.276%, 0.81 +/- 0.210 kg and 0.66 +/- 0.160 kg, respectively. The effects of lactation period and sampling season on the TDMY, fat content, protein content, fat yield and protein yield were found statistically significant (P<0.01). Statistically significant negative correlations were determined between the TDMY and the fat and protein content, but positive and statistically significant (P<0.01) correlations between the TDMY and the fat and protein yields. In conclusion, it might be stated that the effects of lactation period and sampling season should also be taken into account to improve milk yield and milk components.Öğe Erythrocyte potassium and glutathione polymorphism determination in Saanen x Malta crossbred goats(Academic Journals, 2011) Gürcan, Eser Kemal; Çobanoglu, Özden; Köse, MerveThis research is aimed at determining the erythrocyte potassium and glutathione polymorphisms and also to identify the relationship among the various blood parameters in Saanen x Malta crossbred goat raised in Turkey. The allele gene frequencies of K-H and K-L associated with the potassium concentration were calculated as 0.94 and 0.06, respectively. The differences between the mean values of low and high potassium concentrations in erythrocyte were statistically significant (P < 0.01). In addition, there were some significant relationships between erythrocyte potassium types and some blood parameters such as whole blood sodium and potassium concentrations, erythrocyte sodium and potassium concentrations and total monovalent cation concentration in erythrocyte (P < 0.05). The allele gene frequencies of GSH(H) and GSH(h) related with the glutathione concentration were calculated as 0.43 and 0.57, respectively. The difference between the mean values of low and high glutathione erythrocyte concentrations were also statistically significant (P < 0.01). Finally, the significant correlation coefficient between erythrocyte sodium and potassium concentrations was observed in this study (P < 0.05).Öğe Flexible Alternatives to Modelswidely Used for Describing Growth in Japanese Quail(Pakistan Agricultural Scientists Forum, 2017) Gürcan, Eser Kemal; Çobanoglu, Özden; Kaplan, SelçukMathematical functions for modeling the growth of animals are separated into two groups called fixed and flexible according to their inflection behaviors. The aims of this study were to compare fixed and flexible growth functions and to determine the best fit model for the growth data of Japanese quail. The long term growth patterns of Japanese quail were monitored during 110 days from day-old to slaughtering, and were analyzed. The fixed and flexible models used in the study were Gompertz, Logistic, Von Bertalanffy and Levakovich, Janoschek, Morgan Mercer Flodin, respectively. The differences in weight between growth profiles of female and male birds were tested via profile analysis also known as Repeated MANOVA. The results of Profile Analysis revealed that females' live weights were heavier (P<0.01). In order to evaluate growth functions, the R-2 (coefficient of determination), adjusted R-2 (adjusted coefficient of determination), MSE (mean square error), AIC (Akaike's information criterion) and BIC (Bayesian information criterion) goodness of fit criteria were used. In the study, it was determined that the best fit model from female and male quail growth data on the basis of these goodness of fit criteria is Janoschek model which has a flexible structure. The Janoschek model is not only important because it has a higher number of parameters with biological meaning than the other functions (the mature weight and initial weight parameters), but also because it was not previously used in the modeling of the quail growth.Öğe Genetic Polymorphism of STAT1 and STAT5A Genes in Holstein, Jersey, and Indigenous Cattle Breeds in Turkey(Kafkas Univ, Veteriner Fakultesi Dergisi, 2020) Çobanoglu, Özden; Kul, Ertuğrul; Abaci, Samet Hasan; Gürcan, Eser Kemal; Çankaya, SonerThis study aimed to determine genetic polymorphism in STAT1 and STAT5A genes for dairy cattle and some native cattle breeds in Turkey. 283 Jersey and a total of 472 Holstein cows from two different herds and 93 Grey Steppe, 85 Anatolian Black Cattle, and 66 East Anatolian Red cattle were used in this research. Generally, C allele gene frequency was higher than T allele for STAT1 in all breeds whereas C allele gene frequency was detected higher than G allele for STAT5A in Jersey and East Anatolian Red. On the other hand, G allele gene frequency was higher than C allele in Holstein, Grey Steppe, and Anatolian Black Cattle breeds. The expected deviations from the Hardy-Weinberg Equilibrium were significant only for Jersey breeds for STAT1 gene. Meanwhile, the expected deviation from equilibrium was also significantly different for Holstein in Black Sea Region (BSR), Anatolian Black Cattle and Grey Steppe for the STAT5A gene. FIS values were determined to STAT1 gene as negative for all breeds except for Holstein in Marmara Region (MR). Similarly, this value was determined to STAT5A gene as positive for all breeds except for Holstein in BSR. The genetic distances for two loci were calculated between 0.0029 and 0.1599 among all populations. Depending on the cluster analysis, Holstein in BSR and MR, Anatolian Black Cattle, East Anatolian Red were closely clustered to each other, while Grey Steppe and Jersey were located in completely different clusters. As a conclusion, based on the detected genetic diversity in STAT1 and STAT5A genes, it is possible to make a genetic improvement among bovine breeds raised in Turkey.Öğe Influence of Some Environmental Factors on Milk Yield and Milk Components Traits in Jersey Cows(Parlar Scientific Publications (P S P), 2019) Çobanoglu, Özden; Kul, Ertuğrul; Gürcan, Eser Kemal; Çankaya, Soner; Abaci, Samet Hasan; Ülker, MehmetThis study was conducted to assess the effects of stage of lactation, parity and sampling season on milk yield and milk components in Jersey cows in Karakoy State Farm, Turkey. The data set consisted of 2657 milk records of 204 Jersey cows collected from September 2011 to December 2013. For this purpose, test day milk yield (TDMY) records and milk samples were taken once a month for 10-month period after parturition. The effect of stage of lactation, parity and sampling season on TDMY, fat percentage, protein percentage, fat yield and protein yield were found statistically significant (P<0.01). TDMY were correlated with fat percentage (-0.235) and protein percentage negatively (-0.254) but with fat yield (0.755) and protein yield positively (0.950) (P<0.01). In conclusion, these results suggest animal breeders that the effects of lactation stage, parity and sampling season may be taken into account in husbandry management to improve the milk yield and milk quality in Jersey cows.Öğe Refined mapping of twinning-rate quantitative trait loci on bovine chromosome 5 and analysis of insulin-like growth factor-1 as a positional candidate gene(Oxford Univ Press Inc, 2009) Kim, E. S.; Shi, X.; Çobanoglu, Özden; Weigel, K.; Berger, P. J.; Kirkpatrick, B. W.Twinning in cattle is a complex trait that is associated with economic loss and health issues such as abortion, dystocia, and reduced calf survival. Twinning-rate QTL have been detected previously on BTA5 in the North American Holstein and Norwegian dairy cattle populations and in a USDA herd selected for high twinning rate. In previous work with the North American Holstein population, the strongest evidence for a QTL was obtained from analysis of an extended, multiple-generation family. Using additional animals, an increased density of SNP marker association tests, and a combined linkage and linkage disequilibrium mapping method, we refined the position of this QTL in the North American Holstein population. Two sets of twinning-rate predicted transmitting abilities estimated during 2 different time periods in the North American dairy cattle population were used to provide validation of results. A total of 106 SNP and 3 microsatellites were used to scan the genomic region between 5 and 80 Mb on BTA5. Combined linkage-linkage disequilibrium analysis identified significant evidence for QTL within the 25- to 35-Mb and 64- to 70-Mb regions of BTA5. The IGF-1 gene (IGF1) was examined as a positional candidate gene and an SNP in intron 2 of IGF1 was significantly associated with twinning rate by using both data sets (P = 0.003 and P = 1.05 x 10(-6)). Replication of this association in other cattle populations will be required to examine the extent of linkage disequilibrium with the underlying quantitative trait nucleotide across breeds.
