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The Potential of Microarray Databases to Identify Tissue Specific Genes

dc.contributor.authorKaplan, Selçuk
dc.contributor.authorBoztepe, Saim
dc.contributor.authorArikoglu, Hilal
dc.date.accessioned2022-05-11T14:42:32Z
dc.date.available2022-05-11T14:42:32Z
dc.date.issued2016
dc.identifier.issn1300-6045
dc.identifier.urihttps://doi.org/10.9775/kvfd.2015.13639
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9410
dc.description.abstractTissue specific genes play important roles in development and metabolism. Currently, GenBank has 3363628 GEO Profiles and 397988 microarray data related to various tissues. To evaluate the huge amounts of data and identify tissue specific genes, it is necessary to develop and use new strategies. To that end, this study discusses if microarray and microarray related GEO Profiles are a useful tool to identify new tissue specific genes. In the current study, adipose tissue sellected as a target tissue in order to find new tissue specific genes. Therefore, the human and mouse microarray data were analyzed comparatively. To support the microarray data, adipose tissue related GEO Profiles were selected from PubMed. Subsequently, adipose tissue related microarray and GEO Profiles were analysed simultaneously. According to analysis of microarray and GEO Profiles, Chrdl1 (Chordin-like 1) gene was hypothesized as a novel adipose specific gene. In order to test the hypothesis, RT-PCR analysis were performed for the bovine tissue distribution. As a result, the hypothesis was successfully tested and Chrdl1 gene was found highly specific in bovine adipose tissue than in various other tissues. Thus, it is concluded that microarray and microarray related GEO Profiles are a useful tool to identify new tissue specific genes.en_US
dc.language.isoengen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.identifier.doi10.9775/kvfd.2015.13639
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdipose tissueen_US
dc.subjectAdipose specific geneen_US
dc.subjectChordin-like 1en_US
dc.subjectMicroarrayen_US
dc.subjectAdipose Triglyceride Lipaseen_US
dc.subjectPpar-Gammaen_US
dc.subjectNutritional Regulationen_US
dc.subject3t3-L1 Adipocytesen_US
dc.subjectExpressionen_US
dc.subjectObesityen_US
dc.subjectAdipogenesisen_US
dc.subjectProteinsen_US
dc.subjectInsulinen_US
dc.subjectCloningen_US
dc.titleThe Potential of Microarray Databases to Identify Tissue Specific Genesen_US
dc.title.alternativeMikroarray veritabanlarının doku spesifik genlerin belirlenmesindeki potansiyeli]en_US
dc.typearticleen_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.departmentFakülteler, Veteriner Fakültesi, Zootekni ve Hayvan Besleme Bölümü, Genetik Ana Bilim Dalıen_US
dc.authorid0000-0002-2394-3795
dc.identifier.volume22en_US
dc.identifier.issue1en_US
dc.identifier.startpage29en_US
dc.identifier.endpage35en_US
dc.institutionauthorKaplan, Selçuk
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid56949758800
dc.authorscopusid6602545946
dc.authorscopusid6507174859
dc.authorwosidKaplan, Selçuk/ABA-2299-2020
dc.authorwosidGöçerler, Harun/AAS-2740-2020
dc.identifier.wosWOS:000374311300005en_US
dc.identifier.scopus2-s2.0-84946599992en_US


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