dc.contributor.author | Aktoz, Tevfik | |
dc.contributor.author | Kanter, Mehmet | |
dc.contributor.author | Aktaş, Cevat | |
dc.date.accessioned | 2022-05-11T14:41:24Z | |
dc.date.available | 2022-05-11T14:41:24Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0303-4569 | |
dc.identifier.issn | 1439-0272 | |
dc.identifier.uri | https://doi.org/10.1111/j.1439-0272.2010.01044.x | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/9172 | |
dc.description.abstract | P>The aim of this study was to investigate the protective effect of quercetin (QE) on testicular torsion/detorsion-induced ischaemia-reperfusion (I/R) injury. A total of 24 male Wistar albino rats were divided into three groups: control, I/R and I/R treated with QE; each group contain eight animals. Testicular torsion was created by rotating the left testis 720 degrees in a clockwise direction. The ischaemia period was 5 h and orchiectomy was performed after 5 h of detorsion. QE (15 mg kg-1, i.p.) was administrated only once, 40 min prior to detorsion. Left orchiectomy was performed in all I/R groups. To date, no histopathological changes on testicular torsion/detorsion-induced I/R injury in rats by QE treatment have been reported. Spermatogenesis and mean seminiferous tubule diameter were significantly decreased in I/R groups were compared with the control group. Furthermore, QE treated animals showed an improved histological appearance in I/R group. Our data indicate a significant reduction in the activity of TUNEL, endothelial nitric oxide synthase and a rise in the expression of testosterone in testes tissue of I/R treated with QE therapy. We believe that further preclinical research into the utility of QE may indicate its usefulness as a potential treatment on testes injury after I/R in rats. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.identifier.doi | 10.1111/j.1439-0272.2010.01044.x | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | eNOS | en_US |
dc.subject | quercetin | en_US |
dc.subject | testicular torsion | en_US |
dc.subject | testosterone | en_US |
dc.subject | TUNEL | en_US |
dc.subject | Cell-Specific Apoptosis | en_US |
dc.subject | Nitric-Oxide Synthase | en_US |
dc.subject | Contralateral Testis | en_US |
dc.subject | Delayed Phase | en_US |
dc.subject | Germ-Cells | en_US |
dc.subject | Torsion | en_US |
dc.subject | Tissue | en_US |
dc.subject | Flavonoids | en_US |
dc.subject | Calpain | en_US |
dc.subject | Spermatogenesis | en_US |
dc.title | Protective effects of quercetin on testicular torsion/detorsion-induced ischaemia-reperfusion injury in rats | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Andrologia | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 42 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 376 | en_US |
dc.identifier.endpage | 383 | en_US |
dc.institutionauthor | Aktaş, Cevat | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 13609545500 | |
dc.authorscopusid | 7006356462 | |
dc.authorscopusid | 24436194200 | |
dc.authorwosid | Aktas, Cevat/D-8468-2011 | |
dc.identifier.wos | WOS:000284615100005 | en_US |
dc.identifier.scopus | 2-s2.0-78649546008 | en_US |
dc.identifier.pmid | 21105888 | en_US |