dc.contributor.author | Köse, Duygu | |
dc.contributor.author | Yüksel, Tuğba Nurcan | |
dc.contributor.author | Halıcı, Zekai | |
dc.contributor.author | Çadırcı, Elif | |
dc.contributor.author | Gürbüz, Muhammed Ali | |
dc.date.accessioned | 2022-05-11T14:41:12Z | |
dc.date.available | 2022-05-11T14:41:12Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1308-8742 | |
dc.identifier.uri | https://doi.org/10.5152/eurasianjmed.2021.20342 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/9106 | |
dc.description.abstract | Objective: We designed an experimental model of sepsis in rats to investigate the effects of agomelatine (AGO) on lung tissues using molecular and histopathological methods. Materials and Methods: In our experimental model, the 32 rats were divided into 4 groups: group 1: control group (HEALTHY); group 2: lipopolysaccharide group (LPS); group 3: LPS plus 50 mg/kg AGO group (LPS + AGO50); and group 4: LPS plus 100 mg/kg AGO group (LPS + AGO100). An LPS-induced sepsis model was performed to replicate the pathology of sepsis. Rats from all 4 groups were killed after 12 hours, and their lungs were quickly collected. To investigate the therapeutic strategy, we evaluated tumor necrosis factoralpha (TNF-alpha) and nuclear factor-kappa B (NF-kappa B) messenger RNA expressions by real-time polymerase chain reaction using molecular methods and lung tissue damage indicators using histopathological methods. Results: The expressions of TNF-alpha and NF-kappa B were reduced in the groups treated with AGO. The histopathology results supported the molecular results. Conclusion: In this experimental study, we demonstrated for the first time the positive effects of AGO on LPS-induced sepsis in lung tissue using molecular and histopathological methods, indicating that it contributes to the prevention of lung damage. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Aves | en_US |
dc.identifier.doi | 10.5152/eurasianjmed.2021.20342 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Sepsis | en_US |
dc.subject | agomelatine | en_US |
dc.subject | tumor necrosis factor-alpha | en_US |
dc.subject | nuclear factor-kappa B | en_US |
dc.subject | Melatonin Receptor | en_US |
dc.subject | Animal-Models | en_US |
dc.subject | Mt2 Receptors | en_US |
dc.subject | Sepsis | en_US |
dc.subject | Genes | en_US |
dc.title | The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Eurasian Journal of Medicine | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 53 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 127 | en_US |
dc.identifier.endpage | 131 | en_US |
dc.institutionauthor | Yüksel, Tuğba Nurcan | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 56779839000 | |
dc.authorscopusid | 55367802000 | |
dc.authorscopusid | 6508093438 | |
dc.authorscopusid | 16174252200 | |
dc.authorscopusid | 57218420772 | |
dc.authorwosid | Gurbuz, Muhammet Ali/AAA-4948-2022 | |
dc.identifier.wos | WOS:000660311100011 | en_US |
dc.identifier.scopus | 2-s2.0-85108508720 | en_US |
dc.identifier.pmid | 34177296 | en_US |