dc.contributor.author | Ekici, Özlem | |
dc.contributor.author | Tokyol, Çiğdem | |
dc.contributor.author | Dilek, Fatma Hüsniye | |
dc.contributor.author | Aktepe, Fatma | |
dc.contributor.author | Şahin, Onder | |
dc.contributor.author | Şahin, Dursun Ali | |
dc.date.accessioned | 2022-05-11T14:36:55Z | |
dc.date.available | 2022-05-11T14:36:55Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2149-9063 | |
dc.identifier.uri | https://doi.org/10.4274/meandros.1038 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/8481 | |
dc.description.abstract | Objective: The aim of this study was to investigate the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in gastric carcinomas and lymph node metastasis and their relationship with angiogenesis and prognostic histopathological parameters. Materials and Methods: COX-2 and VEGF expression and microvessel density (MVD) grade identified by antibodies against CD34 were investigated immunohistochemically in 33 patients with gastric carcinoma. Results: The expression of COX-2 was 96.9% in normal mucosa and 87.8% in gastric carcinoma. Although COX-2 expression in mucosa was higher than in carcinoma, the difference was not statistically significant. The COX-2 positivity rates in lymph nodes were significantly higher in patients with vascular invasion (p<0.01). The expression of VEGF was 100% in normal mucosa and 93.9% in gastric carcinoma. VEGF levels in mucosa were significantly higher than in carcinoma (p=0.05). MVD grade in mucosa was significantly higher than in gastric carcinoma (p<0.01). MVD values were significantly higher in poorly differentiated carcinomas than in well and moderately differentiated carcinomas (p<0.05). There was no association between COX-2 and VEGF expression and MVD grade in tumor tissues and metastatic lymph nodes. There was no correlation of clinicopathological parameters with COX-2 and VEGF expression and MVD grade. Conclusion: Our results suggest that the MVD in gastric carcinoma may correlate with tumor grade, but the precise roles of COX-2 and VEGF in gastric cancers are not yet fully understood. Further studies with large series are needed to clarify the importance of COX-2, VEGF and MVD in cancer progression. | en_US |
dc.language.iso | tur | en_US |
dc.publisher | Galenos Yayincilik | en_US |
dc.identifier.doi | 10.4274/meandros.1038 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | COX-2 | en_US |
dc.subject | VEGF | en_US |
dc.subject | angiogenesis | en_US |
dc.subject | gastric carcinoma | en_US |
dc.subject | immunohistochemistry | en_US |
dc.subject | Cell Lung-Cancer | en_US |
dc.subject | Invasive Breast-Carcinoma | en_US |
dc.subject | Prognostic-Significance | en_US |
dc.subject | Microvessel Density | en_US |
dc.subject | Tumor Angiogenesis | en_US |
dc.subject | Overexpression | en_US |
dc.subject | Adenocarcinoma | en_US |
dc.subject | Metastasis | en_US |
dc.subject | Induction | en_US |
dc.subject | Neoplasia | en_US |
dc.title | Cyclooxygenase-2 and Vascular Endothelial Growth Factor Expression and Their Correlation with Angiogenesis in Gastric Carcinomas | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Meandros Medical and Dental Journal | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 1 | en_US |
dc.identifier.endpage | 10 | en_US |
dc.institutionauthor | Şahin, Onder | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorwosid | Aktepe, Fatma/AAF-2184-2019 | |
dc.identifier.wos | WOS:000406499800001 | en_US |