Clinical value of neutrophil to lymphocyte ratio in the region of lower extremity deep venous thrombosis

Abstract

Objectives. Many studies have demonstrated a significant association between cardiovascular disease andneutrophil to lymphocyte ratio (NLR). To our knowledge, no study has been reported in patients with deepvenous thrombosis (DVT) which affecting proximal or distal leg. In this study we analyzed proximal and distalDVT according to the NLR. Methods. This retrospective study was obtained from patients’ records of a tertiaryuniversity hospital between May 2011 to January 2014. A total of 57 patients with the diagnosis of acute primaryDVT and 30 patients as control group included in the study. All of them were confirmed with lower extremityvenous duplex examinations. Of these, 37 examinations with the diagnosis of proximal DVT were comparedto 20 examinations with distal DVT. The groups compared regarding to complete blood counter values. Results.Mean eosinophil level was higher in the distal DVT group (0.28±0.24 vs. 0.12±0.01, p=0.001), whereas medianNLR were higher in the proximal DVT group than the distal DVT group (3.5 [0.5-4.3] vs. 2.3 [1.2-9.7],respectively; p=0.002). In addition, median NLR, leukocyte and neutrophil counts were statistically lower inthe control group than the others (p=0.014, p=0.027 and p=0.004, respectively). Conclusion. NLR, aninexpensive and easily measurable laboratory variable, was independently and significantly associated withthe presence and severity of DVT, especially acute proximal DVT