dc.contributor.author | Sağlam, Mehmet Turgut | |
dc.contributor.author | Bingül, Murat | |
dc.contributor.author | Şenkuytu, Elif | |
dc.contributor.author | Boğa, Mehmet | |
dc.contributor.author | Zorlu, Yunus | |
dc.contributor.author | Kandemir, Hakan | |
dc.contributor.author | Şengül, İbrahim Fazıl | |
dc.date.accessioned | 2022-05-11T14:31:04Z | |
dc.date.available | 2022-05-11T14:31:04Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0022-2860 | |
dc.identifier.issn | 1872-8014 | |
dc.identifier.uri | https://doi.org/10.1016/j.molstruc.2020.128308 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/7307 | |
dc.description.abstract | A number of bis-indolyl imine helical structures has successfully been synthesized employing Schiff base reaction conditions starting from 4,6-dimethoxy-2,3-diphenylindole with different o-phenyl diamines as pi-spacer bridged. The structures of targeted compounds were identified by FT-IR, mass, H-1 and C-13 NMR spectroscopy along with single crystal X-ray diffraction techniques. The ground state absorption properties of the bis-indolyl compounds were also investigated utilizing UV-Vis absorption spectroscopy. As the biological aspect of the synthesized compounds, the anticholinesterase potency was investigated towards the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. The highest inhibition was determined in the presence of compound 9 with the values of 89.21 and 96.06, better than standard Galantamine, for AChE and BChE, respectively. (C) 2020 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | Research Found of the Gebze Technical University [2019-A-105-37] | en_US |
dc.description.sponsorship | This work has been supported by Research Found of the Gebze Technical University (Project Number: 2019-A-105-37). We thank to Dr. Michael Dieter Worle for his support in refining compound 10. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.identifier.doi | 10.1016/j.molstruc.2020.128308 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Indole | en_US |
dc.subject | Schiff base | en_US |
dc.subject | UV-Vis | en_US |
dc.subject | Cholinesterase inhibitor | en_US |
dc.subject | Acetylcholinesterase Inhibitors | en_US |
dc.subject | Biological-Activity | en_US |
dc.subject | Base Derivatives | en_US |
dc.subject | Schiff-Bases | en_US |
dc.subject | Antibacterial | en_US |
dc.subject | Complexes | en_US |
dc.subject | Analogs | en_US |
dc.subject | Bis(Indolyl)Methane | en_US |
dc.subject | Chemosensors | en_US |
dc.subject | Antifungal | en_US |
dc.title | Synthesis, characterization, UV-Vis absorption and cholinesterase inhibition properties of bis-indolyl imine ligand systems | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Molecular Structure | en_US |
dc.department | Fakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.authorid | 0000-0002-7347-2223 | |
dc.authorid | 0000-0001-9386-4892 | |
dc.authorid | 0000-0002-3579-8062 | |
dc.identifier.volume | 1215 | en_US |
dc.institutionauthor | Kandemir, Hakan | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57201682024 | |
dc.authorscopusid | 26029066300 | |
dc.authorscopusid | 34168278000 | |
dc.authorscopusid | 35866927300 | |
dc.authorscopusid | 24280865300 | |
dc.authorscopusid | 55326408200 | |
dc.authorscopusid | 55308985300 | |
dc.authorwosid | k, h/ABA-1339-2020 | |
dc.authorwosid | saglam, mehmet/Y-7456-2019 | |
dc.authorwosid | Şenkuytu, Elif/ABI-5315-2020 | |
dc.authorwosid | Sengul, Ibrahim Fazil/AAG-4368-2019 | |
dc.identifier.wos | WOS:000537220200005 | en_US |
dc.identifier.scopus | 2-s2.0-85083710608 | en_US |