dc.contributor.author | Akçılar, Raziye | |
dc.contributor.author | Yümün, Gündüz | |
dc.contributor.author | Donbaloğlu, Mehmet Okan | |
dc.contributor.author | Erselcan, Kubilay | |
dc.contributor.author | Bayat, Zeynep | |
dc.contributor.author | Genç, Osman | |
dc.date.accessioned | 2022-05-11T14:12:47Z | |
dc.date.available | 2022-05-11T14:12:47Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1936-2625 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/5673 | |
dc.description.abstract | Apelin and apelin receptor (APJ) are required for normal cardiovascular development. To investigate the relationship between the APJ G212A polymorphisms and plasma APJ levels and the risk of coronary artery disease (CAD), allele and genotype frequencies of the APJ G212A gene were analysed in were analysed in 152 Turkish patients with CAD and 110 controls by the PCR-RFLP method. The frequencies of genotype GG (57.2% vs 18.2%, P = 0.000, OR = 0.21, 95% CI 0.1 to 0.44) and frequencies of allele G (70.1% vs 46.8%, P = 0.000, OR = 2.65, 95% CI 1.84 to 3.83) at APJ G212A gene polymorphisms were significantly increased in CAD compared with controls. Although plasma APJ level of the patients with GG genotype was lower, It was not statistically significant. CAD patients had significantly lower plasma APJ levels as compared with controls (P = 0.018). On the basis of our results, patients with CAD seem to have lower APJ levels and higher APJ-212 GG genotype and G allele. These results suggested that the APJ G212A gene may be associated with risk for CAD and the APJ G212A gene may play a role in CAD in the Turkish population. | en_US |
dc.description.sponsorship | Dumlupinar UniversityDumlupinar University [2014/49] | en_US |
dc.description.sponsorship | This study was supported by Dumlupinar University Research Fund (Project No. 2014/49). The authors are greatful to Dumlupinar Research Center (DPU-ILTEM) for using the laboratory and equipments, to Didem Ocak and Arif Soylu for their help in experimental research. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | E-Century Publishing Corp | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | APJ G212A gene | en_US |
dc.subject | coronary artery disease | en_US |
dc.subject | polymorphism | en_US |
dc.subject | Turkish population | en_US |
dc.subject | Receptor Gene | en_US |
dc.subject | Apelin | en_US |
dc.subject | Heart | en_US |
dc.subject | Ligand | en_US |
dc.title | Association of APJ G212A gene polymorphisms with plasma APJ levels and coronary artery disease risk in Turkish population | en_US |
dc.type | article | en_US |
dc.relation.ispartof | International Journal of Clinical and Experimental Pathology | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-4720-1945 | |
dc.identifier.volume | 9 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 3793 | en_US |
dc.identifier.endpage | 3798 | en_US |
dc.institutionauthor | Yümün, Gündüz | |
dc.institutionauthor | Donbaloğlu, Mehmet Okan | |
dc.institutionauthor | Erselcan, Kubilay | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorwosid | AKCILAR, Raziye/A-5351-2018 | |
dc.identifier.wos | WOS:000377594100126 | en_US |