dc.contributor.author | Güzel, Savaş | |
dc.contributor.author | Serin, Ozden | |
dc.contributor.author | Güzel, Eda Çelik | |
dc.contributor.author | Büyük, Banu | |
dc.contributor.author | Yılmaz, Guzin | |
dc.contributor.author | Guvenen, Güvenç | |
dc.date.accessioned | 2022-05-11T14:12:33Z | |
dc.date.available | 2022-05-11T14:12:33Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1226-3303 | |
dc.identifier.uri | https://doi.org/10.3904/kjim.2013.28.2.165 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/5599 | |
dc.description.abstract | Background/Aims: Acute coronary syndrome (ACS) is characterized by increased inflammatory processes and endothelial activation. We investigated the association between ACS and inflammatory mediators and matrix-degrading enzymes. Methods: We prospectively enrolled 55 consecutive patients with ACS: 25 with unstable angina (UA) and 30 with non-ST elevated myocardial infarction (NSTEMI). For comparison, 25 age- and sex-matched subjects with no significant coronary artery stenosis were included as the control group. Peripheral serum levels of interleukin (IL)-33, matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP-1, and C-reactive protein (CRP) were measured on admission, and at 12, 24, 48, and 72 hours after the initial evaluation. Results: Compared to serum levels in the control group, serum levels of IL-33 decreased in the NSTEMI group (p < 0.05), and levels of MMP-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 increased in the UA group (p < 0.01, p < 0.05, respectively) and NSTEMI group (p < 0.05, p < 0.05, respectively). IL-33 levels were significantly lower on admission than at 12 hours after the initial evaluation (p < 0.05). IL-33 levels were negatively correlated with MMP-9 levels (r = -0.461, p < 0.05) and CRP levels (r = p < 0.05). Conclusions: Elevated levels of MMP-9, TIMP-1, and decreased levels of IL-33 play a role in the development and progression of ACS. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Korean Assoc Internal Medicine | en_US |
dc.identifier.doi | 10.3904/kjim.2013.28.2.165 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Coronary-Artery-Disease | en_US |
dc.subject | Inflammatory Cytokines | en_US |
dc.subject | T-Lymphocytes | en_US |
dc.subject | Atherosclerosis | en_US |
dc.subject | Macrophages | en_US |
dc.subject | Il-33 | en_US |
dc.subject | St2 | en_US |
dc.subject | Expression | en_US |
dc.subject | Rupture | en_US |
dc.subject | Plaque | en_US |
dc.title | Interleukin-33, matrix metalloproteinase-9, and tissue inhibitor of matrix metalloproteinase-1 in myocardial infarction | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Korean Journal of Internal Medicine | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 165 | en_US |
dc.identifier.endpage | 173 | en_US |
dc.institutionauthor | Güzel, Savaş | |
dc.institutionauthor | Güzel, Eda Çelik | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 23968920100 | |
dc.authorscopusid | 6506182946 | |
dc.authorscopusid | 42661653300 | |
dc.authorscopusid | 55635008600 | |
dc.authorscopusid | 55634874600 | |
dc.authorscopusid | 6507815831 | |
dc.identifier.wos | WOS:000315703300007 | en_US |
dc.identifier.scopus | 2-s2.0-84875492228 | en_US |
dc.identifier.pmid | 23525523 | en_US |