What is the Effect of Pseudoexfoliation Syndrome on Renal Function in Patients without Glaucoma?

Abstract

Purpose: To evaluate renal function in patients with pseudoexfoliation syndrome. Materials and Methods: This prospective, cross-sectional, case-control study involved 49 patients with pseudoexfoliation syndrome (PEX) and 42 control subjects. Renal function was examined by biochemical parameters and Doppler ultrasonography. Serum creatinine, blood urea nitrogen, urea levels, urine microalbumin level and creatinine clearance were measured. Renal volume, resistive index and pulsatility index were calculated using Doppler ultrasonography. Results: The mean laboratory values for both groups were as follows: Creatinine, PEX: 0.81 +/- 0.28 mg/dL - Control: 0.79 +/- 0.22 mg/dL; urea, PEX: 31.6 +/- 9.7 mg/dL - Control: 32.2 +/- 8.4 mg/dL; blood urea nitrogen, PEX: 14.8 +/- 4.6 mg/dL - Control: 15.1 +/- 4.0 mg/dL; creatinine clearance, PEX: 89.1 +/- 35.6 mL/min - Control: 99.0 +/- 47.2 mL/min; microalbumin, PEX: 5.8 +/- 22.7 mg/dL - Control: 2.7 +/- 6.0 mg/dL. The differences between groups were not significant (p > 0.300). Renal volume, resistive index and pulsatility index values were similar in both groups (p > 0.200). Conclusions: This study showed that pseudoexfoliation syndrome does not affect biochemical and ultrasonographic parameters associated with renal function.