dc.contributor.author | Erboğa, Mustafa | |
dc.contributor.author | Aktaş, C. | |
dc.contributor.author | Kurt, Ömer | |
dc.contributor.author | Uygur, Ramazan | |
dc.contributor.author | Çağlar, Veli | |
dc.contributor.author | Turan, Bünyamin Cüneyt | |
dc.contributor.author | Özen, Oğuz Aslan | |
dc.date.accessioned | 2022-05-11T14:07:32Z | |
dc.date.available | 2022-05-11T14:07:32Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0303-4569 | |
dc.identifier.issn | 1439-0272 | |
dc.identifier.uri | https://doi.org/10.1111/and.12436 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/5138 | |
dc.description.abstract | The objective of this study was to examine the effects of thymoquinone (TQ), which has antioxidant properties in the experimental testicular I/R model in rats in terms of its anti-apoptotic, proliferative and biochemical attributes. In our study, 24 male rats were divided into three groups: control group, I/R group and I/R+TQ group. Testicular torsion was created by rotating the left testis 720 degrees in a clockwise direction. The ischaemia period was 4h, and an orchiectomy was performed after 4h of detorsion. Spermatogenesis and the mean seminiferous tubule diameter were significantly decreased in the I/R groups compared to the control group. Furthermore, TQ-treated animals displayed an improved histological appearance in the I/R group. It was also observed that treatment with TQ increased the activity of PCNA, which decreased as a result of I/R, and this treatment also reduced the number of TUNEL-positive cells. The I/R+TQ group showed a decrease in malondialdehyde levels and an increase in the activities of superoxide dismutase, catalase and glutathione peroxidase in comparison with the I/R group. It could be concluded that cytoprotective effects of TQ on the I/R testicles are via reduction of apoptosis, oxidative stress and lipid peroxidation. | en_US |
dc.description.sponsorship | Namik Kemal University Research Center, Tekirdag, TurkeyNamik Kemal University [NKU-BAP.00.20.AR.13.05] | en_US |
dc.description.sponsorship | This study was supported under Project NKU-BAP.00.20.AR.13.05 by the Namik Kemal University Research Center, Tekirdag, Turkey. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.identifier.doi | 10.1111/and.12436 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | ischaemia and reperfusion | en_US |
dc.subject | oxidative stress | en_US |
dc.subject | testis | en_US |
dc.subject | thymoquinone | en_US |
dc.subject | Lipid-Peroxidation | en_US |
dc.subject | Seminiferous Tubules | en_US |
dc.subject | Chronic Ethanol | en_US |
dc.subject | Rat | en_US |
dc.subject | Melatonin | en_US |
dc.subject | Torsion | en_US |
dc.subject | Testis | en_US |
dc.subject | Damage | en_US |
dc.subject | Death | en_US |
dc.title | Protective effects of thymoquinone on experimental testicular ischaemia-reperfusion injury: an apoptotic, proliferative and biochemical study | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Andrologia | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 222 | en_US |
dc.identifier.endpage | 230 | en_US |
dc.institutionauthor | Erboğa, Mustafa | |
dc.institutionauthor | Aktaş, C. | |
dc.institutionauthor | Kurt, Ömer | |
dc.institutionauthor | Uygur, Ramazan | |
dc.institutionauthor | Çağlar, Veli | |
dc.institutionauthor | Turan, Bünyamin Cüneyt | |
dc.institutionauthor | Özen, Oğuz Aslan | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 36023238400 | |
dc.authorscopusid | 24436194200 | |
dc.authorscopusid | 57216014831 | |
dc.authorscopusid | 26434076100 | |
dc.authorscopusid | 25647609500 | |
dc.authorscopusid | 56414492000 | |
dc.authorscopusid | 37058172000 | |
dc.authorwosid | Aktas, Cevat/D-8468-2011 | |
dc.identifier.wos | WOS:000370224300013 | en_US |
dc.identifier.scopus | 2-s2.0-84957441056 | en_US |
dc.identifier.pmid | 26011095 | en_US |