dc.contributor.author | Kayıkçı, Ömür | |
dc.contributor.author | Mehtap, Ö. | |
dc.contributor.author | Sarı, İ. | |
dc.contributor.author | Demirkan, F. | |
dc.contributor.author | Beyan, C. | |
dc.contributor.author | Çetin, G. | |
dc.contributor.author | Tekgündüz, E. | |
dc.contributor.author | Akpınar, Seval | |
dc.date.accessioned | 2023-04-20T08:04:17Z | |
dc.date.available | 2023-04-20T08:04:17Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1300-7777 | |
dc.identifier.uri | https://doi.org/10.4274/tjh.galenos.2022.2022.0052 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/11069 | |
dc.description.abstract | Objective: Peripheral T-cell lymphomas (PTCLs) are an uncommon and quite heterogeneous group of disorders, representing only 10%-15% of all non-Hodgkin lymphomas. Although both molecular and clinical studies have increased in recent years, we still have little knowledge regarding real-life practice with PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes of a large population-based cohort of patients presenting with systemic non-cutaneous PTCL. Materials and Methods: We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016. Results: Considering all first-line treatment combinations, the overall response rate was 65.9% with 49.4% complete remission (n=81) and 16.5% partial response (n=27). The 5-year overall survival and event-free survival rates were significantly different between the transplant and non-transplant groups (p<0.01, and p=0.033, respectively). Conclusion: The retrospective analysis of a large volume of real-life data on the Turkish experience regarding non-cutaneous PTCL patients showed consistent results compared to other unselected PTCL cohorts with some minor differences in terms of survival and transplantation outcomes. The long-term outcome of patients who receive autologous hematopoietic cell transplantation as part of upfront consolidation or salvage therapy is favorable compared to patients who are unable to receive high-dose therapy. © 2022 by Turkish Society of Hematology Turkish Journal of Hematology, Published by Galenos Publishing House. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Turkish Society of Hematology | en_US |
dc.identifier.doi | 10.4274/tjh.galenos.2022.2022.0052 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Autologous stem cell transplantation | en_US |
dc.subject | Lymphomas | en_US |
dc.subject | Non-Hodgkin lymphoma | en_US |
dc.subject | T-cell lymphomas | en_US |
dc.subject | anaplastic lymphoma kinase | en_US |
dc.subject | fluorodeoxyglucose f 18 | en_US |
dc.subject | antineoplastic agent | en_US |
dc.subject | abdomen | en_US |
dc.subject | adult | en_US |
dc.subject | anaplastic large cell lymphoma | en_US |
dc.subject | Article | en_US |
dc.subject | autologous hematopoietic stem cell transplantation | en_US |
dc.subject | autologous stem cell transplantation | en_US |
dc.subject | biopsy | en_US |
dc.subject | bone marrow biopsy | en_US |
dc.subject | cancer patient | en_US |
dc.subject | cancer prognosis | en_US |
dc.subject | cancer survival | en_US |
dc.subject | computer assisted tomography | en_US |
dc.subject | female | en_US |
dc.subject | hematopoietic cell | en_US |
dc.subject | human | en_US |
dc.subject | human tissue | en_US |
dc.subject | International Prognostic Index | en_US |
dc.subject | liver function test | en_US |
dc.subject | lymph node | en_US |
dc.subject | male | en_US |
dc.subject | multicenter study | en_US |
dc.subject | neck | en_US |
dc.subject | Non Cutaneous Peripheral T Cell Lymphoma | en_US |
dc.subject | nonhodgkin lymphoma | en_US |
dc.subject | overall response rate | en_US |
dc.subject | overall survival | en_US |
dc.subject | pelvis | en_US |
dc.subject | peripheral T cell lymphoma | en_US |
dc.subject | physical examination | en_US |
dc.subject | positron emission tomography | en_US |
dc.subject | progression free survival | en_US |
dc.subject | remission | en_US |
dc.subject | retrospective study | en_US |
dc.subject | risk factor | en_US |
dc.subject | salvage therapy | en_US |
dc.subject | thorax | en_US |
dc.subject | transplantation | en_US |
dc.subject | treatment outcome | en_US |
dc.subject | autotransplantation | en_US |
dc.subject | clinical trial | en_US |
dc.subject | hematology | en_US |
dc.subject | hematopoietic stem cell transplantation | en_US |
dc.subject | pathology | en_US |
dc.subject | peripheral T cell lymphoma | en_US |
dc.subject | procedures | en_US |
dc.subject | treatment outcome | en_US |
dc.subject | Antineoplastic Combined Chemotherapy Protocols | en_US |
dc.subject | Hematology | en_US |
dc.subject | Hematopoietic Stem Cell Transplantation | en_US |
dc.subject | Humans | en_US |
dc.subject | Lymphoma, T-Cell, Peripheral | en_US |
dc.subject | Retrospective Studies | en_US |
dc.subject | Transplantation, Autologous | en_US |
dc.subject | Treatment Outcome | en_US |
dc.title | Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG) | en_US |
dc.title.alternative | Non-kutanöz Periferik T-hücreli Lenfomalarda Klinik Özellikler ve Tedavi Sonuçlarına ilişkin Gerçek Yaşam Deneyimi:Türk Hematoloji Araştırma ve Eğitim Grubunun Çok Merkezli Çalışması | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Turkish Journal of Hematology | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.identifier.volume | 39 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 170 | en_US |
dc.identifier.endpage | 177 | en_US |
dc.institutionauthor | Akpınar, Seval | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 37002887000 | |
dc.authorscopusid | 16203384500 | |
dc.authorscopusid | 57867202100 | |
dc.authorscopusid | 7005094713 | |
dc.authorscopusid | 7003953248 | |
dc.authorscopusid | 56348383300 | |
dc.authorscopusid | 6603070081 | |
dc.identifier.scopus | 2-s2.0-85137000431 | en_US |
dc.identifier.pmid | 35678126 | en_US |