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Key Role for Activin B in Cellular Transformation after Loss of the von Hippel-Lindau Tumor Suppressor
(Amer Soc Microbiology, 2009)
The von Hippel-Lindau tumor suppressor gene (VHL) is mutated in clear cell renal cell carcinomas (RCC), leading to the activation of hypoxia-inducible factor (HIF)-mediated gene transcription. Several VHL/HIF targets, such ...