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Toplam kayıt 30, listelenen: 1-10
Effect of hesperetin on systemic inflammation and hepatic injury after blunt chest trauma in rats
(Taylor and Francis Ltd, 2020)
We investigated the protective effect of hesperetin on hepatic damage after blunt chest trauma in rats using histological and biochemical methods. We used 18 adult male rats in three groups of six: control, chest trauma ...
Piperlongumine increases the apoptotic effect of doxorubicin and paclitaxel in a cervical cancer cell line
(Wolters Kluwer Medknow Publications, 2020)
Objective: Piperlongumine (PL) is an alkaloid derived from the edible pepper (Piper longum L) and it has been described to have various biologic activities including anticancer effects. Our aim in this study was to assess ...
Target-Driven Design of a Coumarinyl Chalcone Scaffold Based Novel EF2 Kinase Inhibitor Suppresses Breast Cancer Growth in Vivo
(American Chemical Society, 2021)
Eukaryotic elongation factor 2 kinase (eEF-2K) is an unusual alpha kinase involved in protein synthesis through phosphorylation of elongation factor 2 (EF2). eEF-2K is highly overexpressed in breast cancer, and its activity ...
Long noncoding RNA ERICD interacts with ARID3A via E2F1 and regulates migration and proliferation of osteosarcoma cells
(Blackwell Publishing Ltd, 2020)
Long noncoding RNA (lncRNA) dysregulation is known to be taking part in majority of cancers, including osteosarcoma. In one of our previous studies, we showed that lncRNA MEG3 is being regulated by microRNA-664a (miR-664a) ...
Cardioprotective effects of fish omega-3 fatty acids on doxorubicin-induced cardiotoxicity in rats
(Sage Publications Ltd, 2014)
The aim of this study was to investigate the protective effects of fish omega-3 (n-3) fatty acids on doxorubicin (DOX)-induced acute cardiotoxicity. A total of 24 rats were divided into three groups: control, DOX-treated, ...
Decreased ovarian reserve in female Sprague-Dawley rats induced by isotretinoin (retinoic acid) exposure
(Elsevier Sci Ltd, 2013)
Isotretinoin is a retinoid widely used for the treatment of severe nodulocystic acne. Although it has broad side effects, there is no well-designed study about its effects on the ovary. This study investigated possible ...
Protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes
(Sage Publications Inc, 2016)
This study aimed to investigate the protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes. A total of 27 male rats were divided into 3 groups: control (saline: 5 ml kg(-1) ...
Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney
(Taylor & Francis Ltd, 2016)
We aimed to investigate the protective role of thymoquinone (TQ) by targeting its antiapoptotic and antioxidant properties against kidney damage induced by arsenic in rats. We have used the 24 male Sprague-Dawley rats. ...
Sıçanlarda arseniğin sebep olduğu testiküler hasara karşı kuersetinin koruyucu etkileri
(Namık Kemal Üniversitesi, 2015)
Arsenik hava, su ve toprakta bulunan toksik bir metaldir. Dünya genelinde milyonlarca insanı etkileyen arsenik özellikle erkek üreme sistemi üzerine sitotoksik etki göstermektedir. Çalışmamızda arsenik maruziyetiyle ...
Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats
(Sage Publications Inc, 2014)
The goal of this study was to evaluate the possible protective effects of melatonin against cholestatic oxidative stress, liver damage and hepatocyte apoptosis in the common rats with bile duct ligation (BDL). A total of ...