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Increased serum G72 protein levels in patients with schizophrenia: a potential candidate biomarker
(Cambridge Univ Press, 2017)
Objective: The product of the G72 gene is an activator of d-amino acid oxidase and has been suggested to play a role in the pathogenesis of schizophrenia. Increased G72 protein levels may be associated with disturbed ...
Clinical implications of fluvoxamine and fluoxetine with sigma-1 receptor chaperone activity in the treatment of neuropsychiatric disorders
(Nova Science Publishers, Inc., 2015)
Selective serotonin reuptake inhibitors (SSRIs) are used as therapeutic drugs for a number of neuropsychiatric diseases throughout the world. Although all SSRIs act by blockading serotonin transporters, leading to elevated ...
Reduced serum paraoxonase 1 (PON1) activity in patients with schizophrenia treated with olanzapine but not quetiapine
(Dove Medical Press Ltd, 2013)
Background: Second generation antipsychotics (SGAs) are currently the most prescribed drugs in the treatment of schizophrenia. Despite their advantages, which include greater improvement in negative symptoms, cognitive ...
Sigma-1 Receptor Agonists and Their Clinical Implications in Neuropsychiatric Disorders
(Springer International Publishing Ag, 2017)
Accumulating evidence suggests that sigma-1 receptors play a role in the pathophysiology of neuropsychiatric diseases, as well as in the mechanisms of some selective serotonin reuptake inhibitors (SSRIs). Among the SSRIs, ...
Benefical Effects of Sigma-1 Agonist Fluvoxamine for Tardive Dyskinesia and Tardive Akathisia in Patients with Schizophrenia: Report of Three Cases
(Korean Neuropsychiatric Assoc, 2013)
Fluvoxamine is a selective serotonin reuptake inhibitor that is approved for psychiatric disorders such as major depressive episodes and obsessive-compulsive disorder. Beside inhibition of serotonin reuptake, fluvoxamine ...
Decreased serum levels of brain-derived neurotrophic factor in schizophrenic patients with deficit syndrome
(Dove Medical Press Ltd, 2015)
Background: Brain-derived neurotrophic factor (BDNF) is a well-established neurotrophin that plays a role in the pathophysiology of numerous psychiatric disorders. Many studies have investigated the serum BDNF levels in ...
Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study
(Dove Medical Press Ltd, 2016)
Background: Schizophrenia is a chronic and debilitating disorder, the etiology of which remains unclear. Apoptosis is a programmed cell death mechanism that might be implicated in neuropsychiatric disorders, including ...