Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures
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info:eu-repo/semantics/openAccessTarih
2020Yazar
Kaya, Yasin EmreKaraarslan, Numan
Yılmaz, İbrahim
Şirin, Duygu Yaşar
Yaman, Onur
Özbek, Hanefi
Ateş, Özkan
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AbstractAim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells and the extracellular matrix.Material and Methods: Cartilage tissues of patients (n = 8) were used for the preparation of primary cell cultures. Tigecycline-treated cell cultures served as the study group. Non-treated cell cultures served as the control group. Analyses were performed at 0, 24, 48, and 72 h in both groups. The results obtained were statistically evaluated. The alpha significance value was determined to be 0.05.Results: Proliferation remained unchanged in the tigecycline-treated cell cultures. The gene expressions of the markers involved in anabolic pathways increased in the tigecycline-treated cell cultures. The results obtained were statistically significant (P < 0.05).Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment.
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https://doi.org/10.5455/annalsmedres.2019.11.780https://app.trdizin.gov.tr/makale/TXpZeE9URXlNZz09
https://hdl.handle.net/20.500.11776/5547